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In early 1993, the genetic data implicating the amyloid precursor protein as one of the loci leading to early onset Alzheimer's disease were reviewed (Hardy and Duff, Annals of Medicine, 25: 437–440 ...
Alzheimer ’ s disease (AD) is the most common type of dementia, accounting for 60% to 80% of all cases [...] International Journal of Molecular Sciences Editorial Pathogenesis of Alzheimer’s ...
Alzheimer ' s disease is a neurodegenerative disorder characterized by the massive and invariant accumulation of amyloid plaques in the brains of affected patients. In many cases Alzheimer ' s ...
. Familial Alzheimer’s disease (FAD) is a rare early-onset genetic form of common dementia of old age. Striking in middle age, FAD is caused by missense mutations in three genes: APP (encoding the amyloid ...
used in text: AD â Alzheimerâ s disease ; AβPP â amyloid β-protein precursor; PS1 â presenilin 1; PS2 â presenilin 2; APOE â apolipoprotein E. 1. Introduction Alzheimerâ s Disease (AD ...
Genetic factors are involved in the aetiology of Alzheimer's disease (AD) in 25–40% of the cases. In some cases AD clearly segregates as an autosomal dominant trait in families. Three genes have been ...
In the course of the biochemical efforts devoted to elucidation of the cause( s ) and mechanism( s ) of neurodegeneration in Alzheimer’s disease (AD), much attention has been given to the processes ...
enhanced our knowledge of the mechanism of amyloid formation and increased the potential for effective therapeutic treatment. Ralf Baumeister* and Stefan Eimer Alzheimer s disease is today the most common ...
in an amyloid precursor protein/ Keywords: Alzheimer’s disease , β- amyloid peptides, presenilin -1 double transgenic mouse model of AD. amyloid precursor protein/ presenilin -1 double transgenic mouse model, ...
indicating that altered insulin growth factor I signalling may be involved in the mechanism of action of β- amyloid and famililal Alzheimer ' s disease -causing gene mutations have reawakened interest ...
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