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A Prospective Study of Blood Transfusion Use in Children Undergoing Elective Surgery Using Preoperative Recombinant Erythropoietin (rh-EPO Procrit)

A Prospective Study of Blood Transfusion Use in Children Undergoing Elective Surgery Using Preoperative Recombinant Erythropoietin (rh-EPO Procrit)

Abstract

Clinical Paper and Poster AbstractsA Prospective Study of Blood Transfusion Use in Children Undergoing Elective Surgery Using Preoperative Recombinant Erythropoietin (rh-EPO Procrit) SAGE Publications, Inc.1999DOI: 10.1177/104345429901600229 Heidi Klingele BSN, RN Texas Oncology Pediatrics, Dallas, TX Emily Massey BSN, RN Texas Oncology Pediatrics, Dallas, TX Laurie Macleod RN Texas Oncology Pediatrics, Dallas, TX Jeffrey Fearon MD Texas Oncology Pediatrics, Dallas, TX Joel Weinthal MD Texas Oncology Pediatrics, Dallas, TX A randomized trial is currently being conducted on comparing the safety and efficacy of a weekly erythropoietin dosing regimen in children undergoing elective cranial vault - surgery. The purpose of this study is to determine if preoperative use of Procrit can result in a significant decrease or total elimination of blood transfusions in children undergoing this surgical procedure. Background: Cranial vault remodeling is one of the more common procedures performed in pediatric craniofacial surgical centers. This procedure is usually undertaken from 3 months to 1 year of life, which coincides with a child's natural red cell nadir. The average blood volume replacement during cranial vault surgery is approximately, 10 to 20 mL/kg. Erythropoietin is a glycoprotein hormone that simulates red blood cell production in the bone marrow. Procrit has been
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