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The nuclear envelope and the architecture of the nuclear periphery.

The nuclear envelope and the architecture of the nuclear periphery. then demonstrated with special clarity in the nuclear microdissection experiments of Kite (6) . Further support for the existence of a true nuclear membrane structure, which was profoundly different in composition and molecular organization from the nuclear and cytoplasmic zones, was obtained by polarization microscopy . In these studies the nuclear membrane showed negative spherite birefringence, indicative of lamellar arrays parallel to the nuclear surface (7, 8). Disappearance and finally reversion of the character of this birefringence in imbibition series reported by Schmitt (9) then was interpreted to show that the lamellar structures responsible for the negative spherite appearance was a result of form birefringence and that the intrinsic birefringence of the nuclear membrane resulted from layers of molecules, probably lipids, oriented perpendicularly to the plane of the nuclear membrane . However, the demonstration of the significance and the unique mode of organization of the nuclear membrane has been made possible only by the development of electron microscopic preparation techniques (10-20 ; for more complete and detailed treatment of literature see reviews in references 21-23) . The nuclear envelope as the structure of the nucleocytoplasmic borderland has always been suggestive of being biologically important and, also because of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

The nuclear envelope and the architecture of the nuclear periphery.

W W Franke; U Scheer; G Krohne; E D Jarasch
The Journal of Cell Biology , Volume 91 (3): 39s – Dec 1, 1981
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References (16)

Publisher
Rockefeller University Press
Copyright
Copyright © 1981 by The Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb.91.3.39s
Publisher site
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Abstract

then demonstrated with special clarity in the nuclear microdissection experiments of Kite (6) . Further support for the existence of a true nuclear membrane structure, which was profoundly different in composition and molecular organization from the nuclear and cytoplasmic zones, was obtained by polarization microscopy . In these studies the nuclear membrane showed negative spherite birefringence, indicative of lamellar arrays parallel to the nuclear surface (7, 8). Disappearance and finally reversion of the character of this birefringence in imbibition series reported by Schmitt (9) then was interpreted to show that the lamellar structures responsible for the negative spherite appearance was a result of form birefringence and that the intrinsic birefringence of the nuclear membrane resulted from layers of molecules, probably lipids, oriented perpendicularly to the plane of the nuclear membrane . However, the demonstration of the significance and the unique mode of organization of the nuclear membrane has been made possible only by the development of electron microscopic preparation techniques (10-20 ; for more complete and detailed treatment of literature see reviews in references 21-23) . The nuclear envelope as the structure of the nucleocytoplasmic borderland has always been suggestive of being biologically important and, also because of

Journal

The Journal of Cell Biology – Rockefeller University Press

Published: Dec 1, 1981

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