Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Hogan, H. Wein, L. Wordeman, J. Scholey, K. Sawin, W. Cande (1993)
Inhibition of anaphase spindle elongation in vitro by a peptide antibody that recognizes kinesin motor domain.Proceedings of the National Academy of Sciences of the United States of America, 90 14
Y. Sekine, Y. Okada, Y. Noda, S. Kondo, H. Aizawa, R. Takemura, Nobutaka Hirokawa (1994)
A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentallyThe Journal of Cell Biology, 127
H. Goodson, S. Kang, S. Endow (1994)
Molecular phylogeny of the kinesin family of microtubule motor proteins.Journal of cell science, 107 ( Pt 7)
J. Aist, C. Bayles, W. Tao, M. Berns (1991)
Direct experimental evidence for the existence, structural basis and function of astral forces during anaphase B in vivo.Journal of cell science, 100 ( Pt 2)
Hong Liao, Gang Li, T. Yen (1994)
Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein.Science, 265 5170
S. Henikoff (1984)
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.Gene, 28 3
Mullins Jm, Biesele Jj (1977)
Terminal phase of cytokinesis in D-98S cellsThe Journal of Cell Biology, 73
C. Dingwall, R. Laskey (1991)
Nuclear targeting sequences--a consensus?Trends in biochemical sciences, 16 12
Margaret Fuller, J. Caulton, J. Hutchens, Thomas Kaufman, Elizabeth Raft (1987)
Genetic analysis of microtubule structure: a beta-tubulin mutation causes the formation of aberrant microtubules in vivo and in vitroThe Journal of Cell Biology, 104
Nicholas Brown, F. Kafatos, F. Kafatos (1988)
Functional cDNA libraries from Drosophila embryos.Journal of molecular biology, 203 2
P. Gunaratne, A. Mansukhani, S. Lipari, H. Liou, D. Martindale, M. Goldberg (1986)
Molecular cloning, germ-line transformation, and transcriptional analysis of the zeste locus of Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America, 83 3
F. Sanger, S. Nicklen, A. Coulson (1977)
DNA sequencing with chain-terminating inhibitors.Proceedings of the National Academy of Sciences of the United States of America, 74 12
David ronarde, Kent McDona, Rubai Ding, J. McIn (1993)
Interpolar spindle microtubules in PTK cellsThe Journal of Cell Biology, 123
J. Garnier, D. Osguthorpe, B. Robson (1978)
Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.Journal of molecular biology, 120 1
V. Dombrádi, J. Axton, D. Glover, P. Cohen (1989)
Cloning and chromosomal localization of Drosophila cDNA encoding the catalytic subunit of protein phosphatase 1 alpha. High conservation between mammalian and insect sequences.European journal of biochemistry, 183 3
D. Castrillon, P. Gönczy, S. Alexander, R. Rawson, C. Eberhart, S. Viswanathan, S. DiNardo, S. Wasserman (1993)
Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis.Genetics, 135 2
J. Mohler (1977)
Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development.Genetics, 85 2
Isabelle Vernos, J. Heasman, Chris Wylie (1993)
Multiple kinesin-like transcripts in Xenopus oocytes.Developmental biology, 157 1
W. Saxton, J. McIntosh (1987)
Interzone microtubule behavior in late anaphase and telophase spindlesThe Journal of Cell Biology, 105
R. Rappaport, R. Rappaport, B. Rappaport, B. Rappaport (1974)
Establishment of cleavage furrows by the mitotic spindle.The Journal of experimental zoology, 189 2
A. Lupas, M. Dyke, J. Stock (1991)
Predicting coiled coils from protein sequencesScience, 252
(1994)
A cytological dissection of Drosophila melanogaster spermatogenesis
J. Aist, Hong Liang, Michael Berns (1993)
Astral and spindle forces in PtK2 cells during anaphase B: a laser microbeam study.Journal of cell science, 104 ( Pt 4)
J. Devereux, P. Haeberli, O. Smithies (1984)
A comprehensive set of sequence analysis programs for the VAXNucleic acids research, 12 1 Pt 1
M. Jiménez, C. Goday (1993)
A centrosome-associated antibody from Drosophila melanogaster reveals a new microtubule-dependent structure in the equatorial zone of Parascaris univalens embryos.Journal of cell science, 106 ( Pt 3)
H. Robertson, C. Preston, R. Phillis, D. Johnson-Schlitz, Wendy Benz, W. Engels (1988)
A stable genomic source of P element transposase in Drosophila melanogaster.Genetics, 118 3
J. Ault, C. Rieder (1994)
Centrosome and kinetochore movement during mitosis.Current opinion in cell biology, 6 1
M. Fuller, J. Caulton, J. Hutchens, T. Kaufman, Elizabeth Raft (1988)
Mutations that encode partially functional beta 2 tubulin subunits have different effects on structurally different microtubule arraysThe Journal of Cell Biology, 107
R. Rappaport (1986)
Establishment of the mechanism of cytokinesis in animal cells.International review of cytology, 105
Douglas Cavener, Stuart Ray (1991)
Eukaryotic start and stop translation sites.Nucleic acids research, 19 12
C. Pisano, S. Bonaccorsi, M. Gatti (1993)
The kl-3 loop of the Y chromosome of Drosophila melanogaster binds a tektin-like protein.Genetics, 133 3
(1972)
The anatomy and function of a segment of the X chromosome of Drosophila melanogaster.Genetics, 71 1
B. Williams, Tim Karr, John Montgomery, Michael Goldberg (1992)
The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onsetThe Journal of Cell Biology, 118
(1982)
Mechanics of anaphase B movement
S. Endow, M. Titus (1992)
Genetic approaches to molecular motors.Annual review of cell biology, 8
Margarete Heck, Andrea Pereira, Patty Pesavento, Yvonne Yannoni, Allan Spradling, Lawrence Goldstein (1993)
The kinesin-like protein KLP61F is essential for mitosis in DrosophilaThe Journal of Cell Biology, 123
B. Neighbors, R. Williams, J. Mcintosh (1988)
Localization of kinesin in cultured cellsThe Journal of Cell Biology, 106
K. Kawamura (1977)
Microdissection studies on the dividing neuroblast of the grasshopper, with special reference to the mechanism of unequal cytokinesis.Experimental cell research, 106 1
(1984)
Female sterile mutations in the Iowa collection
D. Lindsley, G. Zimm (1992)
The Genome of Drosophila Melanogaster
L. Goldstein (1993)
With apologies to scheherazade: tails of 1001 kinesin motors.Annual review of genetics, 27
J. Mcintosh, C Pfarr (1991)
Mitotic motorsThe Journal of Cell Biology, 115
M. Hoyt, Ling He, K. Loo, William Saunders (1992)
Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assemblyThe Journal of Cell Biology, 118
S. Endow, M. Hatsumi (1991)
A multimember kinesin gene family in Drosophila.Proceedings of the National Academy of Sciences of the United States of America, 88
W. Cande, Kent McDonald (1985)
In vitro reactivation of anaphase spindle elongation using isolated diatom spindlesNature, 316
A. Bajer, J. Molé-Bajer (1982)
Asters, poles, and transport properties within spindlelike microtubule arrays.Cold Spring Harbor symposia on quantitative biology, 46 Pt 1
Caterina Sellitto, R. Kuriyama (1988)
Distribution of a matrix component of the midbody during the cell cycle in Chinese hamster ovary cellsThe Journal of Cell Biology, 106
Drosophila KLP3A
B. Williams, M. Goldberg (1994)
Determinants of Drosophila zw10 protein localization and function.Journal of cell science, 107 ( Pt 4)
Sambrook, Teri (1989)
Molecular Cloning A Laboratory Manual Second Edition Sambrook
D. Sullivan, T. Huffaker (1992)
Astral microtubules are not required for anaphase B in Saccharomyces cerevisiaeThe Journal of Cell Biology, 119
Joy Yang, W. Saxton, Russell Stewart, E. Raff, Lawrence Goldstein (1990)
Evidence that the head of kinesin is sufficient for force generation and motility in vitro.Science, 249 4964
J. Casal, C. Gonzalez, F. Wandosell, J. Ávila, P. Ripoll (1990)
Abnormal meiotic spindles cause a cascade of defects during spermatogenesis in asp males of Drosophila.Development, 108 2
R. Klemenz, U. Weber, W. Gehring (1987)
The white gene as a marker in a new P-element vector for gene transfer in Drosophila.Nucleic acids research, 15 10
P. Andreassen, Douglas Palmer, M. Wener, Robert Margolis (1991)
Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis.Journal of cell science, 99 ( Pt 3)
Margaret Fuller, J. Caulton, J. Hutchens, Thomas Kaufman, Elizabeth Raft (1988)
Mutations That Encode Partially Functional 132 Tubulin Subunits Have Different Effects on Structurally Different Microtubule Arrays
Cayetano Gonzalez, Robert Saunders, José Casal, Isabel Molina, Mar Carmena, Pedro Ripoll, David Glover (1990)
Mutations at the asp locus of Drosophila lead to multiple free centrosomes in syncytial embryos, but restrict centrosome duplication in larval neuroblasts.Journal of cell science, 96 ( Pt 4)
T. Yen, Gang Li, B. Schaar, Illya Szilak, D. Cleveland (1992)
CENP-E is a putative kinetochore motor that accumulates just before mitosisNature, 359
(1986)
Roles of microtubules in pronuclear migration and spindle elongation in sand dollar eggs
Joy Yang, R. Laymon, Lawrence Goldstein (1989)
A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analysesCell, 56
J. Mcintosh, Story Landis (1971)
THE DISTRIBUTION OF SPINDLE MICROTUBULES DURING MITOSIS IN CULTURED HUMAN CELLSThe Journal of Cell Biology, 49
JC Waters, RW Cole, CL Rieder (1993)
The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each asterThe Journal of Cell Biology, 122
C. Nislow, V. Lombillo, R. Kuriyama, J. Mclntosh (1992)
A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindlesNature, 359
We describe here a new member of the kinesin superfamily in Drosophila, KLP3A (Kinesin-Like-Protein-at-3A). The KLP3A protein localizes to the equator of the central spindle during late anaphase and telophase of male meiosis. Mutations in the KLP3A gene disrupt the interdigitation of microtubules in spermatocyte central spindles. Despite this defect, anaphase B spindle elongation is not obviously aberrant. However, cytokinesis frequently fails after both meiotic divisions in mutant testes. Together, these findings strongly suggest that the KLP3A presumptive motor protein is a critical component in the establishment or stabilization of the central spindle. Furthermore, these results imply that the central spindle is the source of signals that initiate the cleavage furrow in higher cells.
The Journal of Cell Biology – Rockefeller University Press
Published: May 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.