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STUDIES ON THE MECHANISM OF HYDROGEN TRANSPORT IN ANIMAL TISSUES

STUDIES ON THE MECHANISM OF HYDROGEN TRANSPORT IN ANIMAL TISSUES 1. The effect of ribonuclease on various enzyme systems was studied as one approach to the problem of whether or not these enzymes are contained in macromolecules of ribonucleoprotein nature in protoplasm. 2. Ribonuclease inhibited CoI-cytochrome c reductase, succinic dehydrogenase, and cytochrome oxidase, all of which require cytochrome c in order to function. Ribonuclease did not act on cytochrome c . 3. Ribonuclease did not inhibit urease, xanthine oxidase, catalase, alkaline phosphatase, or adenosine triphosphatase under the conditions employed. 4. It was suggested that ribonuclease acted sterically by preventing contact between cytochrome c and its activating centers. 5. It was suggested that the enzymes inhibited may be contained in a ribonucleoprotein of macromolecular dimensions but that the enzymes not inhibited are not necessarily excluded from such a complex by the data presented. 6. Further evidence against the Szent-Györgyi theory of hydrogen transport was presented and discussed. Footnotes Submitted: 25 January 1943 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of General Physiology Rockefeller University Press

STUDIES ON THE MECHANISM OF HYDROGEN TRANSPORT IN ANIMAL TISSUES

The Journal of General Physiology , Volume 26 (5): 443 – May 20, 1943

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References (9)

Publisher
Rockefeller University Press
Copyright
© 1943 Rockefeller University Press
ISSN
0022-1295
eISSN
1540-7748
DOI
10.1085/jgp.26.5.443
Publisher site
See Article on Publisher Site

Abstract

1. The effect of ribonuclease on various enzyme systems was studied as one approach to the problem of whether or not these enzymes are contained in macromolecules of ribonucleoprotein nature in protoplasm. 2. Ribonuclease inhibited CoI-cytochrome c reductase, succinic dehydrogenase, and cytochrome oxidase, all of which require cytochrome c in order to function. Ribonuclease did not act on cytochrome c . 3. Ribonuclease did not inhibit urease, xanthine oxidase, catalase, alkaline phosphatase, or adenosine triphosphatase under the conditions employed. 4. It was suggested that ribonuclease acted sterically by preventing contact between cytochrome c and its activating centers. 5. It was suggested that the enzymes inhibited may be contained in a ribonucleoprotein of macromolecular dimensions but that the enzymes not inhibited are not necessarily excluded from such a complex by the data presented. 6. Further evidence against the Szent-Györgyi theory of hydrogen transport was presented and discussed. Footnotes Submitted: 25 January 1943

Journal

The Journal of General PhysiologyRockefeller University Press

Published: May 20, 1943

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