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The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans. To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene. Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4 + T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease. Footnotes Abbreviations used: AD, atopic dermatitis; dox, doxycycline; H&E, hematoxylin and eosin; NLC, normal littermate control; TSLP, thymic stromal lymphopoietin. J. Yoo and M. Omori contributed equally to this work. Submitted: 28 July 2004 Accepted: 7 July 2005
The Journal of Experimental Medicine – Rockefeller University Press
Published: Aug 15, 2005
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