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P. Hashimoto (1971)
Morphological Studies on the Mechanism of Adrenergic Transmission in the Central Nervous System II. Minute VesiclesProgress in Brain Research, 34
H. Hartline (1969)
Visual receptors and retinal interaction.Science, 164 3877
R. Purple, F. Dodge (1965)
Interaction of excitation and inhibition in the eccentric cell in the eye of Limulus.Cold Spring Harbor symposia on quantitative biology, 30
(1966)
The dynamics of lateral inhibition
(1961)
Inhibitory interaction in the retina and its significance in vision
W. Quay (1963)
Differential extractions for the spectrophotofluorometric measurement of diverse 5-hydroxy- and 5-methoxyindoles.Analytical biochemistry, 5
R. Maickel, Raymond Cox, Jean Saillant, Francis Miller (1968)
A method for the determination of serotonin and norepinephrine in discrete areas of rat brain.International journal of neuropharmacology, 7 3
M. Gur, R. Purple, R. Whitehead (1972)
Ultrastructure within the Lateral Plexus of the Limulus EyeThe Journal of General Physiology, 59
(1969)
Fluorometry of 5-hydroxytryptamine (serotonin). Fluorescence News
(1966)
Excitation and inhibition of electrical activity in the Limulus eye by neuropharmacological agents. In Functional Organization of the Compound Eye
(1966)
Pigment migration and retinular sensitivity
T. Hökfelt (1971)
Ultrastructural Localization of Intraneuronal Monoamines Some Aspects on MethodologyProgress in Brain Research, 34
F. Miller, R. Maickel (1970)
Fluorometric determination of indole derivatives.Life sciences. Pt. 1: Physiology and pharmacology, 9 13
(1971)
Pineal-brain relationships. In The Pineal Gland
S. Ishii (1971)
Morphological Studies on the Mechanism of Adrenergic Transmission in the Central Nervous System I. Granulated VesiclesProgress in Brain Research, 34
Gerschenfeld Hm (1966)
Chemical transmitters in invertebrate nervous systems.Symposia of the Society for Experimental Biology, 20
M. Behrens, V. Wulff (1970)
Neuropharmacological modification of response characteristics of sense cells in the Limulus lateral eye.Vision research, 10 8
O. Eränkö (1971)
Histochemistry of nervous transmission
M. Wolbarsht, S. Yeandle (1967)
Visual processes in the Limulus eye.Annual review of physiology, 29
(1965)
Dynamics of inhibitory interactions in the eye of Limulus: experimental and theoretical studies
C. Fischer, M. Aprison (1972)
Determination of nanomole levels of 5-hydroxytryptophan, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in the same sample.Analytical biochemistry, 46 1
V. Erspamer (1966)
5-Hydroxytryptamine and Related Indolealkylamines
The response to light of one ommatidium is reduced or suppressed by simultaneous illumination of neighboring ommatidia. The mechanism of this lateral inhibition may be chemical synaptic transmission, based on the physiological findings of a number of investigators and on the following evidence. The fine structure of the neuropil of the lateral plexus exhibits numerous clear vesicles (ca. 400 A), dense-core vesicles (ca. 700–1400 A), Golgi regions, and other morphological features of neurochemical synapses. The indolealkylamine, serotonin (5-HT), even in nanomolar concentrations, has a potent inhibitory action. An initial, potent inhibitory dose of 5-HT produces a long lasting densensitization to subsequent doses. The desensitization affects lateral inhibition evoked by light stimulation of neighboring receptors, i.e. crossed-desensitization. Eye tissue extracts contain 5-HT and melatonin (MLT) at a level greater than 1 µg/g wet tissue and perhaps as high as 20–30 µg/g, as determined by two-dimensional thin-layer chromatography (TLC) and o -phthaldialdehyde fluorescence assay techniques. Subcellular fractionation on sucrose gradient indicates a peak in 5-HT and MLT content associated with an intermediate density fraction. 5-HT may be an inhibitory transmitter for lateral inhibition. One pathway for metabolism of 5-HT in the lateral eye may be via N -acetylserotonin and melatonin. Footnotes Submitted: 26 May 1972
The Journal of General Physiology – Rockefeller University Press
Published: Dec 1, 1972
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