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Robert Ménard: Tailing malaria parasites to the red blood cell

Robert Ménard: Tailing malaria parasites to the red blood cell <h2>Robert Ménard: Tailing malaria parasites to the red blood cell</h2> hbashyam@rockefeller.edu Next Section Text and Interview by Hema Bashyam Robert Ménard is stalking the malaria parasite Plasmodium from the moment it invades the skin to find a way to stop its infection cycle. The most elusive period in Plasmodium 's life cycle spans from the moment a human feels the sting of an infected mosquito to the time the victim starts to shiver—a sign that the parasite has infected the red blood cells. During this interval, the bugs are few in number, and they dash to the liver at high speeds. Robert Ménard At the Pasteur Institute in Paris, Robert Ménard spies on the parasites' journey in real-time to figure out how they move and gain access to their various cellular targets. How pathogens sneak into cells is a question that has interested Ménard since the start of his research career. As a Ph.D. student, he identified the proteins that Shigella , the bacterium that causes dysentery, uses to penetrate the gut epithelium ( 1 , 2 ). Later, as a postdoctoral fellow, Ménard discovered that Plasmodium uses a protein called circumsporozoite to both develop inside the mosquito http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

Robert Ménard: Tailing malaria parasites to the red blood cell

The Journal of Experimental Medicine , Volume 205 (4): 744 – Apr 14, 2008

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References (11)

Publisher
Rockefeller University Press
Copyright
© 2008 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.2054pi
pmid
18411342
Publisher site
See Article on Publisher Site

Abstract

<h2>Robert Ménard: Tailing malaria parasites to the red blood cell</h2> hbashyam@rockefeller.edu Next Section Text and Interview by Hema Bashyam Robert Ménard is stalking the malaria parasite Plasmodium from the moment it invades the skin to find a way to stop its infection cycle. The most elusive period in Plasmodium 's life cycle spans from the moment a human feels the sting of an infected mosquito to the time the victim starts to shiver—a sign that the parasite has infected the red blood cells. During this interval, the bugs are few in number, and they dash to the liver at high speeds. Robert Ménard At the Pasteur Institute in Paris, Robert Ménard spies on the parasites' journey in real-time to figure out how they move and gain access to their various cellular targets. How pathogens sneak into cells is a question that has interested Ménard since the start of his research career. As a Ph.D. student, he identified the proteins that Shigella , the bacterium that causes dysentery, uses to penetrate the gut epithelium ( 1 , 2 ). Later, as a postdoctoral fellow, Ménard discovered that Plasmodium uses a protein called circumsporozoite to both develop inside the mosquito

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Apr 14, 2008

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