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R. Amino, D. Giovannini, S. Thiberge, P. Gueirard, B. Boisson, J. Dubremetz, M. Prevost, Tomoko Ishino, M. Yuda, R. Ménard (2008)
Host cell traversal is important for progression of the malaria parasite through the dermis to the liver.Cell host & microbe, 3 2
S. Thiberge, Samantha Blazquez, P. Baldacci, O. Renaud, S. Shorte, R. Ménard, R. Amino (2007)
In vivo imaging of malaria parasites in the murine liverNature Protocols, 2
R. Amino, S. Thiberge, Béatrice Martin, S. Celli, S. Shorte, F. Frischknecht, R. Ménard (2006)
Quantitative imaging of Plasmodium transmission from mosquito to mammalNature Medicine, 12
(2007)
Nat. Protoc
R. Ménard, A. Sultan, Claudio Cortés, R. Altszuler, M. Dijk, C. Janse, A. Waters, R. Nussenzweig, V. Nussenzweig (1997)
Circumsporozoite protein is required for development of malaria sporozoites in mosquitoesNature, 385
C. Press (2007)
Cell host & microbe
(2006)
Nat. Med
R. Ménard, P. Sansonetti, C. Parsot (1993)
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cellsJournal of Bacteriology, 175
R. Ménard, P. Sansonetti, C. Parsot, T. Vasselon (1994)
Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneriCell, 79
A. Sturm, R. Amino, C. Sand, Tommy Regen, Silke Retzlaff, Annika Rennenberg, A. Krueger, J. Pollok, R. Ménard, V. Heussler (2006)
Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver SinusoidsScience, 313
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J. Bacteriol
<h2>Robert Ménard: Tailing malaria parasites to the red blood cell</h2> hbashyam@rockefeller.edu Next Section Text and Interview by Hema Bashyam Robert Ménard is stalking the malaria parasite Plasmodium from the moment it invades the skin to find a way to stop its infection cycle. The most elusive period in Plasmodium 's life cycle spans from the moment a human feels the sting of an infected mosquito to the time the victim starts to shiver—a sign that the parasite has infected the red blood cells. During this interval, the bugs are few in number, and they dash to the liver at high speeds. Robert Ménard At the Pasteur Institute in Paris, Robert Ménard spies on the parasites' journey in real-time to figure out how they move and gain access to their various cellular targets. How pathogens sneak into cells is a question that has interested Ménard since the start of his research career. As a Ph.D. student, he identified the proteins that Shigella , the bacterium that causes dysentery, uses to penetrate the gut epithelium ( 1 , 2 ). Later, as a postdoctoral fellow, Ménard discovered that Plasmodium uses a protein called circumsporozoite to both develop inside the mosquito
The Journal of Experimental Medicine – Rockefeller University Press
Published: Apr 14, 2008
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