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Osteopontin Is Involved in the Initiation of Cutaneous Contact Hypersensitivity by Inducing Langerhans and Dendritic Cell Migration to Lymph Nodes

Osteopontin Is Involved in the Initiation of Cutaneous Contact Hypersensitivity by Inducing... Osteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration of Langerhans cells/dendritic cells (LCs/DCs) from skin to draining lymph nodes. Characterizing OPN function for LC/DC migration we found upregulated OPN expression in hapten sensitized skin and draining lymph nodes. OPN induces chemotactic LC/DC migration, initiates their emigration from the epidermis, and attracts LCs/DCs to draining lymph nodes by interacting with CD44 and αv integrin. Furthermore, OPN-deficient mice have a significantly reduced CHS response that correlates with an impaired ability of OPN-deficient mice to attract LCs/DCs to draining lymph nodes. In conclusion, OPN is an important factor in the initiation of CHS by guiding LCs/DCs from skin into lymphatic organs. dendritic cells Langerhans cells integrins CD44 osteopontin Footnotes ↵ * Abbreviations used in this paper: ANOVA, analysis of variance; CHS, contact hypersensitivity; DC, dendritic cell; ECM, extracellular matrix; LC, Langerhans cell; OPN, osteopontin; TNCB, Trinitro-chloro-benzene. J.M. Weiss and A.C. Renkl contributed equally to this work. Submitted: 20 October 2000 Accepted: 6 September 2001 Revision received 26 July 2001 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

Osteopontin Is Involved in the Initiation of Cutaneous Contact Hypersensitivity by Inducing Langerhans and Dendritic Cell Migration to Lymph Nodes

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Publisher
Rockefeller University Press
Copyright
© 2001 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.194.9.1219
Publisher site
See Article on Publisher Site

Abstract

Osteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration of Langerhans cells/dendritic cells (LCs/DCs) from skin to draining lymph nodes. Characterizing OPN function for LC/DC migration we found upregulated OPN expression in hapten sensitized skin and draining lymph nodes. OPN induces chemotactic LC/DC migration, initiates their emigration from the epidermis, and attracts LCs/DCs to draining lymph nodes by interacting with CD44 and αv integrin. Furthermore, OPN-deficient mice have a significantly reduced CHS response that correlates with an impaired ability of OPN-deficient mice to attract LCs/DCs to draining lymph nodes. In conclusion, OPN is an important factor in the initiation of CHS by guiding LCs/DCs from skin into lymphatic organs. dendritic cells Langerhans cells integrins CD44 osteopontin Footnotes ↵ * Abbreviations used in this paper: ANOVA, analysis of variance; CHS, contact hypersensitivity; DC, dendritic cell; ECM, extracellular matrix; LC, Langerhans cell; OPN, osteopontin; TNCB, Trinitro-chloro-benzene. J.M. Weiss and A.C. Renkl contributed equally to this work. Submitted: 20 October 2000 Accepted: 6 September 2001 Revision received 26 July 2001

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Nov 5, 2001

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