Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Orienting early cleavage

Orienting early cleavage <h2>Orienting early cleavage</h2> Even if the first cleavage is reoriented, one blastomere becomes embryonic (red) and the other abembryonic (blue). ZERNICKA-GOETZ/MACMILLAN The very first division of a mammalian zygote breaks its symmetry, as shown by Berenika Plusa, Magdalena Zernicka-Goetz (University of Cambridge, Cambridge, UK), and colleagues. The early split establishes two halves that already have different developmental characteristics.Using 3D real-time images of dividing embryos, the group shows that the orientation of the first cleavage is not random. Rather, the cleavage furrow tends to form in the proximity of the sperm entry site and near the plane formed by the pronuclei (the sperm and egg genomes) just before they mix. Zygote manipulation revealed an overriding effect of cell shape on cleavage orientation. When zygotes were slightly flattened, the cleavage plane went through the short axis of the cell, no matter where the pronuclei were positioned. Pronuclei usually align along the long axis in flattened zygotes, which may explain why past experiments suggested that the cleavage plane lay between, not parallel to, the pronuclei. The ability to change the zygote's choice of cleavage plane allowed the authors to show that the cleavage itself predicts the blastocyst axis. Whether the cleavage http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

Orienting early cleavage

LeBrasseur, Nicole
The Journal of Cell Biology , Volume 169 (1): 17 – Apr 11, 2005
Download PDF
2 pages

Loading next page...
 
/lp/rockefeller-university-press/orienting-early-cleavage-BbEtGoO90z

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Rockefeller University Press
Copyright
© 2005 Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb1691rr4
Publisher site
See Article on Publisher Site

Abstract

<h2>Orienting early cleavage</h2> Even if the first cleavage is reoriented, one blastomere becomes embryonic (red) and the other abembryonic (blue). ZERNICKA-GOETZ/MACMILLAN The very first division of a mammalian zygote breaks its symmetry, as shown by Berenika Plusa, Magdalena Zernicka-Goetz (University of Cambridge, Cambridge, UK), and colleagues. The early split establishes two halves that already have different developmental characteristics.Using 3D real-time images of dividing embryos, the group shows that the orientation of the first cleavage is not random. Rather, the cleavage furrow tends to form in the proximity of the sperm entry site and near the plane formed by the pronuclei (the sperm and egg genomes) just before they mix. Zygote manipulation revealed an overriding effect of cell shape on cleavage orientation. When zygotes were slightly flattened, the cleavage plane went through the short axis of the cell, no matter where the pronuclei were positioned. Pronuclei usually align along the long axis in flattened zygotes, which may explain why past experiments suggested that the cleavage plane lay between, not parallel to, the pronuclei. The ability to change the zygote's choice of cleavage plane allowed the authors to show that the cleavage itself predicts the blastocyst axis. Whether the cleavage

Journal

The Journal of Cell Biology – Rockefeller University Press

Published: Apr 11, 2005

There are no references for this article.