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No more division

No more division <h2>No more division</h2> DNA synthesis (shown in red) is blocked in cells expressing SC1 (green). The binding partner of a neuronal growth factor (NGF) receptor puts the brakes on cell division, according to results on page 985 by Chittka et al. NGF is a neuronal survival and differentiation factor expressed in the developing nervous system. NGF binds to two different classes of receptors: the TrkA tyrosine kinase receptor and p75NTR. While studying how p75NTR functions in NGF signaling, Chittka and colleagues had previously shown that this receptor interacts with SC1, a zinc finger protein that moves to the nucleus in response to NGF. The group now shows that SC1 is a transcriptional repressor that halts proliferation in cultured cells. NGF activates the repressor, which complexes in the nucleus with histone deacetylases. At least part of the reason for the cell cycle block is that SC1 turns off cyclin E transcription, thus preventing entry into S phase. SC1's repressive activity is enhanced by both TrkA and p75NTR, although physical interaction with SC1 has only been shown for p75NTR. Other genes are probably also repressed by SC1, and the authors hope that upcoming microarray experiments will identify many of them. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

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Publisher
Rockefeller University Press
Copyright
© 2004 Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb1647iti3
Publisher site
See Article on Publisher Site

Abstract

<h2>No more division</h2> DNA synthesis (shown in red) is blocked in cells expressing SC1 (green). The binding partner of a neuronal growth factor (NGF) receptor puts the brakes on cell division, according to results on page 985 by Chittka et al. NGF is a neuronal survival and differentiation factor expressed in the developing nervous system. NGF binds to two different classes of receptors: the TrkA tyrosine kinase receptor and p75NTR. While studying how p75NTR functions in NGF signaling, Chittka and colleagues had previously shown that this receptor interacts with SC1, a zinc finger protein that moves to the nucleus in response to NGF. The group now shows that SC1 is a transcriptional repressor that halts proliferation in cultured cells. NGF activates the repressor, which complexes in the nucleus with histone deacetylases. At least part of the reason for the cell cycle block is that SC1 turns off cyclin E transcription, thus preventing entry into S phase. SC1's repressive activity is enhanced by both TrkA and p75NTR, although physical interaction with SC1 has only been shown for p75NTR. Other genes are probably also repressed by SC1, and the authors hope that upcoming microarray experiments will identify many of them.

Journal

The Journal of Cell BiologyRockefeller University Press

Published: Mar 29, 2004

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