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Neurons inch along

Neurons inch along <h2>Neurons inch along</h2> Centrosome (arrow) moves before nucleus. HATTEN/MACMILLAN Centrosome and nucleus engage in an inchworm-like dance in certain migrating neurons, according to David Solecki, Mary Hatten, and colleagues (Rockefeller University, New York, NY). The neurons under study migrate along glia to form the layered architecture of higher brain areas. Whereas primitive brain areas have a nuclear organization, the cortex builds its more complex circuitry by sending its neurons off on these treks. The neurons were known to move and adhere in a periodic cycle, with a long process leading the way and the nucleus at the rear. But the Rockefeller group now shows that the centrosome moves forward first; the nucleus then closes the gap. This cycle has a similar period to the adhesion cycle. Although the relative timing of the events is not known, coordination may rely on mPar6α, which the Rockefeller group identifies as a centrosome component essential for centrosome and cell movement. The nucleus is surrounded by a perinuclear microtubule cage whose shape is distorted during the cycle. The cage and nucleus are probably moved towards the centrosome by dynein. The movement of the centrosome itself is more of a mystery, both in terms http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

Neurons inch along

Wells, William A.
The Journal of Cell Biology , Volume 167 (3): 396 – Nov 8, 2004
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Publisher
Rockefeller University Press
Copyright
© 2004 Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb1673rr3
Publisher site
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Abstract

<h2>Neurons inch along</h2> Centrosome (arrow) moves before nucleus. HATTEN/MACMILLAN Centrosome and nucleus engage in an inchworm-like dance in certain migrating neurons, according to David Solecki, Mary Hatten, and colleagues (Rockefeller University, New York, NY). The neurons under study migrate along glia to form the layered architecture of higher brain areas. Whereas primitive brain areas have a nuclear organization, the cortex builds its more complex circuitry by sending its neurons off on these treks. The neurons were known to move and adhere in a periodic cycle, with a long process leading the way and the nucleus at the rear. But the Rockefeller group now shows that the centrosome moves forward first; the nucleus then closes the gap. This cycle has a similar period to the adhesion cycle. Although the relative timing of the events is not known, coordination may rely on mPar6α, which the Rockefeller group identifies as a centrosome component essential for centrosome and cell movement. The nucleus is surrounded by a perinuclear microtubule cage whose shape is distorted during the cycle. The cage and nucleus are probably moved towards the centrosome by dynein. The movement of the centrosome itself is more of a mystery, both in terms

Journal

The Journal of Cell Biology – Rockefeller University Press

Published: Nov 8, 2004

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