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Richard Kong, Kin Kwan, Elizabeth Lau, J. Thomas, R. Boot-Handford, M Grant, Kathryn Cheah (1993)
Intron-exon structure, alternative use of promoter and expression of the mouse collagen X gene, Col10a-1.European journal of biochemistry, 213 1
J. Mühlhauser (1986)
Resorption of the unmineralized proximal part of Meckel's cartilage in the rat. A light and electron microscopic study.Journal of submicroscopic cytology, 18 4
R. Cancedda, P. Castagnola, F. Cancedda, B. Dozin, R. Quarto (2000)
Developmental control of chondrogenesis and osteogenesis.The International journal of developmental biology, 44 6
Basic Appl. Histochem., 28
Thiennu Vu, Zena Werb (2000)
Matrix metalloproteinases: effectors of development and normal physiology.Genes & development, 14 17
S. Frisch, R. Screaton (2001)
Anoikis mechanisms.Current opinion in cell biology, 13 5
Development., 124
C. Colnot, J. Helms (2001)
A molecular analysis of matrix remodeling and angiogenesis during long bone developmentMechanisms of Development, 100
M. Galotto, G. Campanile, Grazia Robino, F. Cancedda, P. Bianco, R. Cancedda (1994)
Hypertrophic chondrocytes undergo further differentiation to osteoblast‐like cells and participate in the initial bone formation in developing chick embryoJournal of Bone and Mineral Research, 9
Robert McLean, David Podell (1995)
Bone and joint manifestations of hypothyroidism.Seminars in arthritis and rheumatism, 24 4
L. Blavier, A. Lazaryev, J. Groffen, N. Heisterkamp, Y. DeClerck, V. Kaartinen (2001)
TGF-β3-induced Palatogenesis Requires Matrix MetalloproteinasesMolecular Biology of the Cell, 12
S. Damjanovski, A. Ishizuya‐Oka, Yunbo Shi (1999)
Spatial and temporal regulation of collagenases-3, -4, and stromelysin -3 implicates distinct functions in apoptosis and tissue remodeling during frog metamorphosisCell Research, 9
M. Kaufman (1992)
The Atlas of Mouse Development
M. Egeblad, Z. Werb (2002)
New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2
Haixu Chen, D. Ovchinnikov, C. Pressman, A. Aulehla, Y. Lun, Randy Johnson (1998)
Multiple calvarial defects in lmx1b mutant mice.Developmental genetics, 22 4
L. Blavier, A. Lazaryev, J. Groffen, N. Heisterkamp, Y. DeClerck, V. Kaartinen (2001)
TGF-beta3-induced palatogenesis requires matrix metalloproteinases.Molecular biology of the cell, 12 5
Thiennu Vu, J. Shipley, G. Bergers, Joel Berger, J. Helms, D. Hanahan, S. Shapiro, R. Senior, Z. Werb (1998)
MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic ChondrocytesCell, 93
J. Hanken, C. Summers (1988)
Skull development during anuran metamorphosis: III. Role of thyroid hormone in chondrogenesis.The Journal of experimental zoology, 246 2
J. Vuletin, H. Friedman, W. Gordon (1976)
A Light and Electron Microscopic Study
P. Bianco, A. Ponzi, E. Bonucci (1984)
Basic and 'special' stains for plastic sections in bone marrow histopathology, with special reference to May-Grünwald Giemsa and enzyme histochemistry.Basic and applied histochemistry, 28 3
A. Ishizuya‐Oka, Qing Li, T. Amano, S. Damjanovski, S. Ueda, Yunbo Shi (2000)
Requirement for Matrix Metalloproteinase Stromelysin-3 in Cell Migration and Apoptosis during Tissue Remodeling in Xenopus laevisThe Journal of Cell Biology, 150
W. Monkhouse (1947)
GRAY'S ANATOMYMedical Journal of Australia, 1
F. Coe, M. Favus (1992)
Disorders of bone and mineral metabolismJournal of Pediatric Orthopaedics, 12
Jae‐Chang Jung, K. Leco, D. Edwards, M. Fini (2002)
Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone‐induced tail resorptionDevelopmental Dynamics, 223
H. Gerber, Thiennu Vu, A. Ryan, J. Kowalski, Z. Werb, N. Ferrara (1999)
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formationNature Medicine, 5
H. Väänänen, Haibo Zhao, M. Mulari, J. Halleen (2000)
The cell biology of osteoclast function.Journal of cell science, 113 ( Pt 3)
M. Jiménez, M. Balbín, J. Álvarez, T. Komori, P. Bianco, K. Holmbeck, H. Birkedal‐Hansen, José López, C. López-Otín (2001)
A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formationThe Journal of Cell Biology, 155
Int. J. Dev. Biol., 44
C. Brinckerhoff, L. Matrisian (2002)
Matrix metalloproteinases: a tail of a frog that became a princeNature Reviews Molecular Cell Biology, 3
S. Teitelbaum (2000)
Bone resorption by osteoclasts.Science, 289 5484
M. Riminucci, J. Bradbeer, A. Corsi, C. Gentili, F. Descalzi, R. Cancedda, P. Bianco (1998)
Vis‐à‐Vis Cells and the Priming of Bone FormationJournal of Bone and Mineral Research, 13
M. Seiki (2002)
The cell surface: the stage for matrix metalloproteinase regulation of migration.Current opinion in cell biology, 14 5
Y. Shi, A. Ishizuya‐Oka (2001)
Thyroid hormone regulation of apoptotic tissue remodeling: implications from molecular analysis of amphibian metamorphosis.Progress in nucleic acid research and molecular biology, 65
B. Crombrugghe, Véronique Lefebvre, Kazuhisa Nakashima (2001)
Regulatory mechanisms in the pathways of cartilage and bone formation.Current opinion in cell biology, 13 6
C. Gentili, Paolo Bianco, M. Neri, M. Malpeli, G. Campanile, P. Castagnola, R. Cancedda, F. Cancedda (1993)
Cell proliferation, extracellular matrix mineralization, and ovotransferrin transient expression during in vitro differentiation of chick hypertrophic chondrocytes into osteoblast-like cellsThe Journal of Cell Biology, 122
Deborah Berry, R. Schwartzman, Donald Brown (1998)
The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs.Developmental biology, 203 1
(1873)
Quelques faits relatifs au développment du tissu osseux
H. Birkedal‐Hansen (1995)
Proteolytic remodeling of extracellular matrix.Current opinion in cell biology, 7 5
H. Gray
Gray's Anatomy
Danny Chan, O. Jacenko (1998)
Phenotypic and biochemical consequences of collagen X mutations in mice and humans.Matrix biology : journal of the International Society for Matrix Biology, 17 3
H. Watanabe, Yoshihiko Yamada (1999)
Mice lacking link protein develop dwarfism and craniofacial abnormalitiesNature Genetics, 21
S. Göthe, Zhendong Wang, L. Ng, J. Kindblom, Angel Barros, C. Ohlsson, B. Vennström, D. Forrest (1999)
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.Genes & development, 13 10
Deborah Berry, Christopher Rose, B. Remo, Donald Brown (1998)
The expression pattern of thyroid hormone response genes in remodeling tadpole tissues defines distinct growth and resorption gene expression programs.Developmental biology, 203 1
J. Chin, Zena Werb (1997)
Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch.Development, 124 8
J. Hanken, B. Hall (1988)
Skull development during anuran metamorphosisAnatomy and Embryology, 178
K. Holmbeck, P. Bianco, J. Caterina, S. Yamada, Mark Kromer, S. Kuznetsov, M. Mankani, P. Robey, A. Poole, I. Pidoux, J. Ward, H. Birkedal‐Hansen (1999)
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen TurnoverCell, 99
MT1-MMP mediates metamorphic remodeling in the mouse | Holmbeck et al
I. Loftus, A. Naylor, P. Bell, Molly Thompson (2002)
Matrix metalloproteinases and atherosclerotic plaque instabilityBritish Journal of Surgery, 89
J. Tata (1993)
Early amphibian pattern formation Utrecht, 12–26 September 1993Mechanisms of Development, 41
David Kass, Marlene Rabinovitch, Z. Galis, Jaikirshan Khatri, Biomedical Engineering
This Review Is Part of a Thematic Series on Matrix Metalloproteinases, Which Includes the following Articles: Matrix Metalloproteinase Inhibition after Myocardial Infarction: a New Approach to Prevent Heart Failure? Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis: the Good, the Ba
G. Roodman (1999)
Cell biology of the osteoclast.Experimental hematology, 27 8
Mimi Shirasu-Hiza, Peg Coughlin, Tim Mitchison (2003)
Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purificationThe Journal of Cell Biology, 161
G. Karsenty, E. Wagner (2002)
Reaching a genetic and molecular understanding of skeletal development.Developmental cell, 2 4
F. Shapiro, M. Holtrop, M. Glimcher (1977)
Organization and cellular biology of the perichondrial ossification groove of ranvier: a morphological study in rabbits.The Journal of bone and joint surgery. American volume, 59 6
A. Page-McCaw, J. Serano, Joshua Santé, G. Rubin (2003)
Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.Developmental cell, 4 1
I. Massova, L. Kotra, R. Fridman, S. Mobashery (1998)
Matrix metalloproteinases: structures, evolution, and diversificationThe FASEB Journal, 12
Skeletal tissues develop either by intramembranous ossification, where bone is formed within a soft connective tissue, or by endochondral ossification. The latter proceeds via cartilage anlagen, which through hypertrophy, mineralization, and partial resorption ultimately provides scaffolding for bone formation. Here, we describe a novel and essential mechanism governing remodeling of unmineralized cartilage anlagen into membranous bone, as well as tendons and ligaments. Membrane-type 1 matrix metalloproteinase (MT1-MMP)–dependent dissolution of unmineralized cartilages, coupled with apoptosis of nonhypertrophic chondrocytes, mediates remodeling of these cartilages into other tissues. The MT1-MMP deficiency disrupts this process and uncouples apoptotic demise of chondrocytes and cartilage degradation, resulting in the persistence of “ghost” cartilages with adverse effects on skeletal integrity. Some cells entrapped in these ghost cartilages escape apoptosis, maintain DNA synthesis, and assume phenotypes normally found in the tissues replacing unmineralized cartilages. The coordinated apoptosis and matrix metalloproteinase-directed cartilage dissolution is akin to metamorphosis and may thus represent its evolutionary legacy in mammals. cranial vault; Meckel's cartilage; matrix dissolution; chondrocyte apoptosis; metamorphosis; MT1-MMP Footnotes K. Holmbeck and P. Bianco contributed equally to this work. Abbreviations used in this paper: MC, Meckel's cartilage; MMP, matrix metalloproteinase; MT1-MMP, membrane-type 1 MMP. Submitted: 10 July 2003 Accepted: 17 September 2003
The Journal of Cell Biology – Rockefeller University Press
Published: Nov 10, 2003
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