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Intracellular calcium movements during excitation–contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers

Intracellular calcium movements during excitation–contraction coupling in mammalian slow-twitch... In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions (Ca 2+ ) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers micro-injected with a rapidly responding fluorescent Ca 2+ indicator dye reveal that the amount of Ca 2+ released is three- to fourfold larger in fast-twitch fibers than in slow-twitch fibers, and the proportion of the released Ca 2+ that binds to troponin to activate contraction is substantially smaller. Submitted: 13 January 2012 Accepted: 16 February 2012 This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms ). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ ). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of General Physiology Rockefeller University Press

Intracellular calcium movements during excitation–contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers

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References (189)

Publisher
Rockefeller University Press
Copyright
© 2012 Baylor and Hollingworth
ISSN
0022-1295
eISSN
1540-7748
DOI
10.1085/jgp.201210773
pmid
22450485
Publisher site
See Article on Publisher Site

Abstract

In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions (Ca 2+ ) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers micro-injected with a rapidly responding fluorescent Ca 2+ indicator dye reveal that the amount of Ca 2+ released is three- to fourfold larger in fast-twitch fibers than in slow-twitch fibers, and the proportion of the released Ca 2+ that binds to troponin to activate contraction is substantially smaller. Submitted: 13 January 2012 Accepted: 16 February 2012 This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms ). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ ).

Journal

The Journal of General PhysiologyRockefeller University Press

Published: Apr 1, 2012

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