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One mechanism regulating the ability of different subsets of T helper (Th) cells to respond to cytokines is the differential expression of cytokine receptors. For example, Th2 cells express both chains of the interferon γ receptor (IFN-γR), whereas Th1 cells do not express the second chain of the IFN-γR (IFN-γR2) and are therefore unresponsive to IFN-γ. To determine whether the regulation of IFN-γR2 expression, and therefore IFN-γ responsiveness, is important for the differentiation of naive CD4 + T cells into Th1 cells or for Th1 effector function, we generated mice in which transgenic (TG) expression of IFN-γR2 is controlled by the CD2 promoter and enhancer. CD4 + T cells from IFN-γR2 TG mice exhibit impaired Th1 polarization potential in vitro. TG mice also display several defects in Th1-dependent immunity in vivo, including attenuated delayed-type hypersensitivity responses and decreased antigen-specific IFN-γ production. In addition, TG mice mount impaired Th1 responses against Leishmania major , as manifested by increased parasitemia and more severe lesions than their wild-type littermates. Together, these data suggest that the sustained expression of IFN-γR2 inhibits Th1 differentiation and function. Therefore, the acquisition of an IFN-γ–unresponsive phenotype in Th1 cells plays a crucial role in the development and function of these cells. T helper type 1 cells interferon type II interferon receptors hypersensitivity, delayed cytokines Footnotes Abbreviations used in this paper: CFSE, carboxyfluorescein diacetate succinimidyl ester; DTH, delayed-type hypersensitivity; HKLM, heat-killed Listeria monocytogenes ; STAT, signal transducer and activator of transcription; TG, transgenic; WT, wild-type. Submitted: 6 December 1999 Revision requested 9 June 2000 Accepted: 30 June 2000
The Journal of Experimental Medicine – Rockefeller University Press
Published: Oct 2, 2000
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