Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
<h2>Getting ahead by staying still</h2> The centrosome is fixed even as the nucleus moves to the back of the cell. GUNDERSEN/ELSEVIER Migrating cells send the nucleus backward rather than the microtubule-organizing center (MTOC) forward, say Edgar Gomes, Shantanu Jani, and Gregg Gundersen (Columbia University, New York, NY).As cells begin to migrate, they spin their internal contents around to orient in the direction of overall cell movement. Movement of a MTOC was thought to lead the way in this process. Consistent with this idea, dynein tugged on MTOCs in other settings, and was concentrated at the leading edge of moving cells. The MTOC moving toward the front of a migrating cell “had been our model forever,” says Gundersen. The trouble is, he says, “people weren't looking early enough.” They had seen the final result but not the movement itself. Now, this team gets reorientation going with LPA before initiating migration with serum. That allows them to catch the nucleus moving backward even as the MTOC stays put. The GTPase Cdc42 and its target MRCK were necessary and sufficient for nuclear movement. These proteins prompt actin polymerization at the front of the cell and thus actin retrograde flow, whose timing
The Journal of Cell Biology – Rockefeller University Press
Published: May 23, 2005
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.