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Getting ahead by staying still

Getting ahead by staying still <h2>Getting ahead by staying still</h2> The centrosome is fixed even as the nucleus moves to the back of the cell. GUNDERSEN/ELSEVIER Migrating cells send the nucleus backward rather than the microtubule-organizing center (MTOC) forward, say Edgar Gomes, Shantanu Jani, and Gregg Gundersen (Columbia University, New York, NY).As cells begin to migrate, they spin their internal contents around to orient in the direction of overall cell movement. Movement of a MTOC was thought to lead the way in this process. Consistent with this idea, dynein tugged on MTOCs in other settings, and was concentrated at the leading edge of moving cells. The MTOC moving toward the front of a migrating cell “had been our model forever,” says Gundersen. The trouble is, he says, “people weren't looking early enough.” They had seen the final result but not the movement itself. Now, this team gets reorientation going with LPA before initiating migration with serum. That allows them to catch the nucleus moving backward even as the MTOC stays put. The GTPase Cdc42 and its target MRCK were necessary and sufficient for nuclear movement. These proteins prompt actin polymerization at the front of the cell and thus actin retrograde flow, whose timing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

Getting ahead by staying still

Wells, William A.
The Journal of Cell Biology , Volume 169 (4): 551 – May 23, 2005
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Publisher
Rockefeller University Press
Copyright
© 2005 Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb1694rr4
Publisher site
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Abstract

<h2>Getting ahead by staying still</h2> The centrosome is fixed even as the nucleus moves to the back of the cell. GUNDERSEN/ELSEVIER Migrating cells send the nucleus backward rather than the microtubule-organizing center (MTOC) forward, say Edgar Gomes, Shantanu Jani, and Gregg Gundersen (Columbia University, New York, NY).As cells begin to migrate, they spin their internal contents around to orient in the direction of overall cell movement. Movement of a MTOC was thought to lead the way in this process. Consistent with this idea, dynein tugged on MTOCs in other settings, and was concentrated at the leading edge of moving cells. The MTOC moving toward the front of a migrating cell “had been our model forever,” says Gundersen. The trouble is, he says, “people weren't looking early enough.” They had seen the final result but not the movement itself. Now, this team gets reorientation going with LPA before initiating migration with serum. That allows them to catch the nucleus moving backward even as the MTOC stays put. The GTPase Cdc42 and its target MRCK were necessary and sufficient for nuclear movement. These proteins prompt actin polymerization at the front of the cell and thus actin retrograde flow, whose timing

Journal

The Journal of Cell Biology – Rockefeller University Press

Published: May 23, 2005

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