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GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE

GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE The transfer of spleen cells from (C3H x C57Bl/6) F 1 mice, capable of responding to (T,G)-A--L, into irradiated C3H parental recipients, normally incapable of responding to (T,G)-A--L, transfers the ability to make either a primary or secondary immune response to this synthetic polypeptide antigen. This localizes the genetic control of the ability to respond to the spleen cell population and indicates that the genetic control is exerted upon a process directly related to antibody formation. Studies with congenic strains of mice and linkage studies in segregating backcross populations show that the ability to respond to (T,G)-A--L and (H,G)-A--L is linked to the H-2 locus and can thus be localized to the IXth mouse linkage group. Note Added in Proof : Of the three possible recombinant animals noted in Tables IV and V, two were infertile. The third animal was not a recombinant, since progeny testing and reimmunization showed that this animal was an H-2 2 / H-2 k heterozygote capable of responding well to (T,G)-A--L. Footnotes Submitted: 16 January 1968 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE

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References (11)

Publisher
Rockefeller University Press
Copyright
© 1968 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.128.1.1
Publisher site
See Article on Publisher Site

Abstract

The transfer of spleen cells from (C3H x C57Bl/6) F 1 mice, capable of responding to (T,G)-A--L, into irradiated C3H parental recipients, normally incapable of responding to (T,G)-A--L, transfers the ability to make either a primary or secondary immune response to this synthetic polypeptide antigen. This localizes the genetic control of the ability to respond to the spleen cell population and indicates that the genetic control is exerted upon a process directly related to antibody formation. Studies with congenic strains of mice and linkage studies in segregating backcross populations show that the ability to respond to (T,G)-A--L and (H,G)-A--L is linked to the H-2 locus and can thus be localized to the IXth mouse linkage group. Note Added in Proof : Of the three possible recombinant animals noted in Tables IV and V, two were infertile. The third animal was not a recombinant, since progeny testing and reimmunization showed that this animal was an H-2 2 / H-2 k heterozygote capable of responding well to (T,G)-A--L. Footnotes Submitted: 16 January 1968

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Jul 1, 1968

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