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DEPOSITION OF SILICA IN MITOCHONDRIA: AN ELECTRON MICROSCOPIC STUDY

DEPOSITION OF SILICA IN MITOCHONDRIA: AN ELECTRON MICROSCOPIC STUDY First appearance of dense intramitochondrial deposits (silica) in a portion of mitochondria (arrows). FIGURE O Detail of deposits in two modified mitochondria. The mitochondrion on the left is swollen, with thinned contents and modified cristae. The mitoehondrion on the right remains dense but the cristae have almost disappeared. W E B R I E F N O T E S T h e fate of the siliceous bodies is easily followed. By progressive swelling, the mitochondria break up, the siliceous bodies being freed in the degenerating cytoplasm. W i t h the latter they proceed to the l u m i n a of the u r i n a r y tubule into the casts, with which they are finally eliminated. After 2 days, w h e n the siliceous bodies begin to a p p e a r in the necrotic substance of the casts, the silica content of the whole kidney becomes nearly normal. Recently, the electron microscope has provided us with a means of detecting i n t r a m i t o c h o n d r i a l deposits following silver (Dempsey, 1955) or iron (ferritin, Bessis, 1959) treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

DEPOSITION OF SILICA IN MITOCHONDRIA: AN ELECTRON MICROSCOPIC STUDY

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References (2)

Publisher
Rockefeller University Press
Copyright
Copyright © 1961 by The Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb.9.1.236
Publisher site
See Article on Publisher Site

Abstract

First appearance of dense intramitochondrial deposits (silica) in a portion of mitochondria (arrows). FIGURE O Detail of deposits in two modified mitochondria. The mitochondrion on the left is swollen, with thinned contents and modified cristae. The mitoehondrion on the right remains dense but the cristae have almost disappeared. W E B R I E F N O T E S T h e fate of the siliceous bodies is easily followed. By progressive swelling, the mitochondria break up, the siliceous bodies being freed in the degenerating cytoplasm. W i t h the latter they proceed to the l u m i n a of the u r i n a r y tubule into the casts, with which they are finally eliminated. After 2 days, w h e n the siliceous bodies begin to a p p e a r in the necrotic substance of the casts, the silica content of the whole kidney becomes nearly normal. Recently, the electron microscope has provided us with a means of detecting i n t r a m i t o c h o n d r i a l deposits following silver (Dempsey, 1955) or iron (ferritin, Bessis, 1959) treatment.

Journal

The Journal of Cell BiologyRockefeller University Press

Published: Jan 1, 1961

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