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The Urinary Mucosal Barrier in Retrograde Pyelography: Experimental Findings and Clinical Implications

The Urinary Mucosal Barrier in Retrograde Pyelography: Experimental Findings and Clinical... Radiology 95: 403-409, May 1970 MUCOSAL LINING of the urinary tract has been assumed to be an effective barrier to systemic absorption of contrast material. Hence, many prefer retrograde pyelography to intravenous urography in patients who have shown prior adverse reactions to contrast media. Small volumes of contrast medium permeating the uro-epithelium during retrograde pyelography may represent a risk to a sensitive patient, as deaths have occurred with doses as low as 1 m1 (10). It is known that the hydronephrotic urinary tract permits resorption of macromolecules (11). The following experiments were performed to determine whether the normal nonhydronephrotic urinary collecting system would also allow the passage of contrast medium in circumstances similar to retrograde pyelography. HE MATERIAL AND METHODS Retrograde pyelography using 13lJ-1abe1ed Hypaque'' was carried out on 2 groups of adult dogs under pentobarbital anesthesia. In the first group the intraureteric pressure was maintained after retrograde pyelography. In the second group the kidney was allowed to drain freely after pyelography. Group A: In 10 dogs both ureters were exposed (Fig. 1). The ureter undergoing retrograde pyelography was doubly ligated, divided, proximally cannulated, and connected to a manometer. Approximately 100 fJ.c of 13lJ-1abe1ed diatrizoatewas flushed in with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Radiology Radiological Society of North America, Inc.

The Urinary Mucosal Barrier in Retrograde Pyelography: Experimental Findings and Clinical Implications

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Publisher
Radiological Society of North America, Inc.
Copyright
Copyright © May 1970 by Radiological Society of North America
ISSN
1527-1315
eISSN
0033-8419
Publisher site
See Article on Publisher Site

Abstract

Radiology 95: 403-409, May 1970 MUCOSAL LINING of the urinary tract has been assumed to be an effective barrier to systemic absorption of contrast material. Hence, many prefer retrograde pyelography to intravenous urography in patients who have shown prior adverse reactions to contrast media. Small volumes of contrast medium permeating the uro-epithelium during retrograde pyelography may represent a risk to a sensitive patient, as deaths have occurred with doses as low as 1 m1 (10). It is known that the hydronephrotic urinary tract permits resorption of macromolecules (11). The following experiments were performed to determine whether the normal nonhydronephrotic urinary collecting system would also allow the passage of contrast medium in circumstances similar to retrograde pyelography. HE MATERIAL AND METHODS Retrograde pyelography using 13lJ-1abe1ed Hypaque'' was carried out on 2 groups of adult dogs under pentobarbital anesthesia. In the first group the intraureteric pressure was maintained after retrograde pyelography. In the second group the kidney was allowed to drain freely after pyelography. Group A: In 10 dogs both ureters were exposed (Fig. 1). The ureter undergoing retrograde pyelography was doubly ligated, divided, proximally cannulated, and connected to a manometer. Approximately 100 fJ.c of 13lJ-1abe1ed diatrizoatewas flushed in with

Journal

RadiologyRadiological Society of North America, Inc.

Published: May 1, 1970

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