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Science to Practice: Imaging of Cellular Microparticles—Magic Dust or Just Dirt?

Science to Practice: Imaging of Cellular Microparticles—Magic Dust or Just Dirt? Science to Practice: Imaging of Cellular Microparticles—Magic Dust or Just Dirt? deepdyve.host = 'www.deepdyve.com'; // replace with an affiliateId that we provide deepdyve.affiliateId = "highwire-rsnajnls"; // the div to fill in with the rental link deepdyve.divId = 'rentalLink'; // this is the anchor text for the rental link deepdyve.rentText = "Rent Article for $0.99"; // document identifier and identifier type deepdyve.fieldName = 'journal_mjid'; deepdyve.docId = "radiology;263/1/1"; var callbackToken='4756106F16DFAB4'; GS_googleAddAdSenseService("ca-pub-3649609630781117"); GS_googleEnableAllServices(); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-homepage-leaderboard-728x90"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-homepage-upper_right-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-nonarticlepages-leaderboard-728x90"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-nonarticlepages-upper_right-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-podcasts-upper_right-120x90"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_one-120x300"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_two-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_three-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_four-125x125"); GA_googleFetchAds(); var journalCode = 'radiology'; Skip to main page content HOME CURRENT ARCHIVE COLLECTIONS 中国 (ABSTRACTS) RADIOLOGY SELECT RADIOGRAPHICS RSNA.org Search GO Advanced Search Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In Science to Practice: Imaging of Cellular Microparticles—Magic Dust or Just Dirt? Peter L. Choyke , MD Molecular Imaging Program National Cancer Institute 9000 Rockville Pike, Bldg 10, Room B3B69F Bethesda, MD 20892-1088 pchoyke@mail.nih.gov Summary Al Faraj et al ( 1 ) are to be congratulated on having the insight to label endothelial microparticles (MPs) with iron oxides to image their fate in vivo. Their experiment is a good example of how imaging can be an important scientific tool. By bringing the concept of MPs to the attention of the radiology community, this article stimulates thinking about how to make MPs into imaging agents and/or therapeutic agents. MPs are already making an impact as serum biomarkers. Their size and biology make them challenging to develop as general imaging biomarkers; however, their potential as highly targeted natural drug–imaging carrier platforms for vascular disease should not be ignored because they fulfill so many of the desirable preconditions for such platforms. We are just beginning to understand how to harness this magic “dust” for medical purposes. The Setting When Peter Wolf ( 2 ) first described a halo of debris surrounding activated platelets as “cell dust” in 1967, biologists were puzzled about the purpose of these phospholipid-containing structures. Within the past decade, the emerging science of cellular MPs has revealed that these “dust” particles actually represent a complex system of intercellular communication that are implicated in such diverse conditions as cardiovascular disease, inflammation, and cancer … (Full Text of this Article) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Radiology Radiological Society of North America, Inc.

Science to Practice: Imaging of Cellular Microparticles—Magic Dust or Just Dirt?

Radiology , Volume 263 (1): 1 – Apr 1, 2012

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References (5)

Publisher
Radiological Society of North America, Inc.
Copyright
Copyright © $record{$a_year} by Radiological Society of North America
ISSN
1527-1315
eISSN
0033-8419
DOI
10.1148/radiol.12120076
pmid
22438438
Publisher site
See Article on Publisher Site

Abstract

Science to Practice: Imaging of Cellular Microparticles—Magic Dust or Just Dirt? deepdyve.host = 'www.deepdyve.com'; // replace with an affiliateId that we provide deepdyve.affiliateId = "highwire-rsnajnls"; // the div to fill in with the rental link deepdyve.divId = 'rentalLink'; // this is the anchor text for the rental link deepdyve.rentText = "Rent Article for $0.99"; // document identifier and identifier type deepdyve.fieldName = 'journal_mjid'; deepdyve.docId = "radiology;263/1/1"; var callbackToken='4756106F16DFAB4'; GS_googleAddAdSenseService("ca-pub-3649609630781117"); GS_googleEnableAllServices(); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-homepage-leaderboard-728x90"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-homepage-upper_right-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-nonarticlepages-leaderboard-728x90"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-nonarticlepages-upper_right-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-podcasts-upper_right-120x90"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_one-120x300"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_two-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_three-125x125"); GA_googleAddSlot("ca-pub-3649609630781117", "radiology-toc_ad_four-125x125"); GA_googleFetchAds(); var journalCode = 'radiology'; Skip to main page content HOME CURRENT ARCHIVE COLLECTIONS 中国 (ABSTRACTS) RADIOLOGY SELECT RADIOGRAPHICS RSNA.org Search GO Advanced Search Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In Science to Practice: Imaging of Cellular Microparticles—Magic Dust or Just Dirt? Peter L. Choyke , MD Molecular Imaging Program National Cancer Institute 9000 Rockville Pike, Bldg 10, Room B3B69F Bethesda, MD 20892-1088 pchoyke@mail.nih.gov Summary Al Faraj et al ( 1 ) are to be congratulated on having the insight to label endothelial microparticles (MPs) with iron oxides to image their fate in vivo. Their experiment is a good example of how imaging can be an important scientific tool. By bringing the concept of MPs to the attention of the radiology community, this article stimulates thinking about how to make MPs into imaging agents and/or therapeutic agents. MPs are already making an impact as serum biomarkers. Their size and biology make them challenging to develop as general imaging biomarkers; however, their potential as highly targeted natural drug–imaging carrier platforms for vascular disease should not be ignored because they fulfill so many of the desirable preconditions for such platforms. We are just beginning to understand how to harness this magic “dust” for medical purposes. The Setting When Peter Wolf ( 2 ) first described a halo of debris surrounding activated platelets as “cell dust” in 1967, biologists were puzzled about the purpose of these phospholipid-containing structures. Within the past decade, the emerging science of cellular MPs has revealed that these “dust” particles actually represent a complex system of intercellular communication that are implicated in such diverse conditions as cardiovascular disease, inflammation, and cancer … (Full Text of this Article)

Journal

RadiologyRadiological Society of North America, Inc.

Published: Apr 1, 2012

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