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regimens, administered in pulses or courses, is lacking. Since this article was written, there have been a number of preliminary reports on combined multiple drug and radiotherapy for radiation-responsive tumors which tend to disseminate widely, including Wilms's tumor, rhabdomyosarcoma, Ewing's sarcoma, and Stage III Hodgkin's disease. Treatment of these tumors is directed toward (a) reduction of tumor volume in the primary site and (b) elimination of occult metastases. In the past, the lack of a systematized approach t? treat~ent and reporting in too many instances has resulted m considerable confusion regarding the efficacy of combining cherno- and radiotherapy. A gradual recognition of the need for organized protocols and cooperative clinical trials will undoubtedly escalate the collection of meaningful data for those malignant diseases which are responsive to both modes of treatment. As Dr. Vermund indicates, further progress depends upon the development of chemotherapeutic agents which will enhance the effect of irradiation in resistant tumors. LILLIAN M. FULLER, M. D.
Radiology – Radiological Society of North America, Inc.
Published: Feb 1, 1973
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