CT Measurement of Blood Flow through Lung Cancers Eric N. C. Milne , MD Tigh Ban Lek, Arduaine, Argyll PA34 4XQ, Scotland e-mail: encm@hotmail.com Editor: In “ Assessment of Non–Small Cell Lung Cancer Perfusion: Pathologic-CT Correlation in 15 Patients” ( 1 ), which appeared in the December 2010 issue of Radiology , Dr Tacelli and colleagues list no imaging references prior to the advent of computed tomography (CT). The paucity of pre-CT references may be owing to difficulties in finding earlier articles. The following facts were documented over 40 years ago: 1. Lung tumors are supplied by both bronchial and pulmonary circulations ( 2 ). This article, as confirmed by distinguished respiratory pathologist Averill Liebow (written communication, September 1975), reversed the dogma that lung tumors have a purely bronchial circulation. 2. Peripheral tumors, both primary and metastatic, have a predominantly pulmonary circulation; central tumors have a predominantly bronchial circulation ( 3 , 4 ). Related to this, peripheral tumor perfusion is approximately 2.4 times central tumor perfusion ( 5 ). Dr Tacelli and colleagues suggest that perfusion discrepancies between similar tumors are based on interstital pressure; however, interstitial pressure increases only in tumors within a confined … Full Text of this Article
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CT Measurement of Blood Flow through Lung Cancers
Milne, Eric N. C.
Follow Radiology
, Volume 259 (2): 613
Radiological Society of North America, Inc. – May 1, 2011
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