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Psychopharmacology Copyright 2008 by the American Psychological Association 2008, Vol. 16, No. 5, 386 –399 1064-1297/08/$12.00 DOI: 10.1037/a0013088 Mu / Kappa Opioid Interactions in Rhesus Monkeys : Implications ...
as functional antagonists of cocaine led us to examine their interactions with cocaine's abuse‐related effects in rhesus monkeys . In cocaine self‐administration studies, four arylacetamides (U50,488, enadoline ...
cocaine self- administration by rhesus monkeys . We compared the cardiovascular and subjective effects of acute doses of the mu / kappa opioid nalbuphine alone (5 mg/70 kg, intravenous (i.v.)), with cocaine ...
, rhesus monkey , squirrel monkey , substance abuse, translational Introduction Substance use disorders constitute a class of mental health disorders that pose an insidious public health problem. For example ...
nervous system, including areas implicated in analgesia and affective state. Although kappa opioid receptor agonists share the antinociceptive effects of mu opioid receptor agonists, they also tend ...
, but with different signaling properties (referred to as “bias”). The effect of these differences in signaling is investigated in mice. Introduction The endogenous opioid system consists of the mu , delta, and kappa ...
) receptor, or kappa -type 3 opioid receptor. Opioid receptors are seven-transmembrane domain receptors that couple to intracellular signaling molecules by activating heterotrimeric G proteins [14]. Binding ...
., Woods , J. H., Medzihradsky , F. ( 1994 ) Binding affinity and selectivity of opioids at mu , delta and kappa receptors in monkey brain membrane . J. Pharmacol. Exp. Ther. 271 : 1630 – 1637 . Google ...
) rhesus monkeys (Macaca mulatta, 4.5–8.5 kg) from the Yerkes National Primate Research Center colony were used in this study (Table 1). All procedures were approved by Emory’s Animal Care and Use Committee ...
–1984. Devine, D. P., Leone, P., Pocock, D. and Wise, R. A. ( 1993 ) Differential involvement of ventral tegmental mu , delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release ...
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