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On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells

Proceedings of the National Academy of Sciences , Volume 100 (10): 6021 – May 13, 2003

Details

Publisher
National Acad Sciences
Copyright
Copyright ©2009 by the National Academy of Sciences
ISSN
0027-8424
eISSN
1091-6490
Publisher site
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On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells

Abstract

CD4+ T cells expand after transfer into lymphopenic H-2b Aβ −/− mice (I-Aβ-, I-Eα-deficient mice) but not after transfer into lymphopenic MHC IIΔ/Δ mice (I-Aα-, I-Aβ-, I-Eα-, and I-Eβ-deficient mice), implying that in H-2b Aβ −/− mice, Aα chain and Eβ chain associate to form a hybrid AαEβ MHC class II molecule. In light of this unexpected result, we reexamined the MHC class II requirement in the survival and lymphopenia-induced proliferation of CD4+ T cells. Here we show that expansion, but not short-term survival, of CD4+ T cells depends on interactions with MHC class II molecules in lymphopenic mice. Nevertheless, interactions with classical MHC class II molecules are required for CD4+ T cells to survive in CD8+ T-cell-containing mice.
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