Access the full text.
Sign up today, get DeepDyve free for 14 days.
R. Guéguen, P. Jouanny, Francis Guillemin, C. Kuntz, J. Pourel, G. Siest (1995)
Segregation analysis and variance components analysis of bone mineral density in healthy familiesJournal of Bone and Mineral Research, 10
Gregory Livshits, David Karasik, O. Pavlovsky, E. Kobyliansky (1999)
Segregation analysis reveals a major gene effect in compact and cancellous bone mineral density in 2 populations.Human biology, 71 2
I. Takács, Daniel Koller, M. Peacock, J. Christian, S. Hui, P. Conneally, C. Johnston, T. Foroud, Michael Econs (1999)
Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus.The Journal of clinical endocrinology and metabolism, 84 12
T. Stewart, S. Ralston (2000)
Role of genetic factors in the pathogenesis of osteoporosis.The Journal of endocrinology, 166 2
Matthew Brown, M. Haughton, S. Grant, Anthony Gunnell, N. Henderson, J. Eisman (2001)
Genetic Control of Bone Density and Turnover: Role of the Collagen 1α1, Estrogen Receptor, and Vitamin D Receptor GenesJournal of Bone and Mineral Research, 16
E. Duncan, M. Brown, J. Sinsheimer, J. Bell, A. Carr, Bryan Wordsworth, J. Wass (1999)
Suggestive Linkage of the Parathyroid Receptor Type 1 to OsteoporosisJournal of Bone and Mineral Research, 14
Val Mann, E. Hobson, Baohua Li, Tracy Stewart, S. Grant, S. Robins, R. Aspden, S. Ralston (2001)
A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality.The Journal of clinical investigation, 107 7
R. Duggirala, J. Blangero, L. Almasy, T. Dyer, K. Williams, R. Leach, P. O’Connell, M. Stern (2000)
A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans.American journal of human genetics, 66 4
J. Zmuda, J. Cauley, R. Ferrell (1999)
Recent progress in understanding the genetic susceptibility to osteoporosisGenetic Epidemiology, 16
O. Hill (1968)
A Twin StudyBritish Journal of Psychiatry, 114
D. Allison, M. Neale, R. Zannolli, R. Zannolli, N. Schork, C. Amos, J. Blangero (1999)
Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure.American journal of human genetics, 65 2
L. Spotila, J. Caminis, M. Devoto, K. Shimoya, L. Sereda, J. Ott, M. Whyte, A. Tenenhouse, D. Prockop (1996)
Osteopenia in 37 Members of Seven Families: Analysis Based on a Model of Dominant InheritanceMolecular Medicine, 2
Daniel Koller, Michael Econs, P. Morin, J. Christian, S. Hui, Pauline Parry, M. Curran, Lawrence Rodriguez, P. Conneally, G. Joslyn, M. Peacock, C. Johnston, T. Foroud (2000)
Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis.The Journal of clinical endocrinology and metabolism, 85 9
M. Devoto, K. Shimoya, K. Shimoya, J. Caminis, J. Ott, A. Tenenhouse, M. Whyte, L. Sereda, S. Hall, E. Considine, C. Williams, G. Tromp, G. Tromp, H. Kuivaniemi, H. Kuivaniemi, L. Ala‐kokko, D. Prockop, L. Spotila (1998)
First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4qEuropean Journal of Human Genetics, 6
L. Melton (2000)
Who Has Osteoporosis? A Conflict Between Clinical and Public Health PerspectivesJournal of Bone and Mineral Research, 15
J. Blangero, Jeff Williams, L. Almasy (2001)
Variance component methods for detecting complex trait loci.Advances in genetics, 42
G. Lathrop, J. Lalouel, C. Julier, J. Ott (1984)
Strategies for multilocus linkage analysis in humans.Proceedings of the National Academy of Sciences of the United States of America, 81 11
Daniel Koller, Guangda Liu, M. Econs, S. Hui, P. Morin, G. Joslyn, L. Rodriguez, P. Conneally, J. Christian, C. Johnston, T. Foroud, M. Peacock (2001)
Genome Screen for Quantitative Trait Loci Underlying Normal Variation in Femoral StructureJournal of Bone and Mineral Research, 16
I. Takács, Daniel Koller, M. Peacock, J. Christian, W. Evans, S. Hui, P. Conneally, C. Johnston, T. Foroud, Michael Econs (2000)
Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus.Bone, 27 1
太田 信孝 (2001)
Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis
R. Keen, H. Snieder, H. Molloy, J. Daniels, M. Chiano, F. Gibson, L. Fairbairn, P. Smith, A. MacGregor, D. Gewert, T. Spector (2001)
Evidence of association and linkage disequilibrium between a novel polymorphism in the transforming growth factor beta 1 gene and hip bone mineral density: a study of female twins.Rheumatology, 40 1
L. Cardon, C. Garner, S. Bennett, I. Mackay, R. Edwards, J. Cornish, M. Hegde, M. Murray, I. Reid, T. Cundy (2000)
Evidence for a Major Gene for Bone Mineral Density in Idiopathic Osteoporotic FamiliesJournal of Bone and Mineral Research, 15
Mark Johnson, G. Gong, W. Kimberling, Susan Recker, D. Kimmel, R. Recker (1997)
Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)American journal of human genetics, 60 6
J. Dequeker, J. Nijs, A. Verstraeten, P. Geusens, G. Gevers (1987)
Genetic determinants of bone mineral content at the spine and radius: a twin study.Bone, 8 4
N. Pocock, J. Eisman, J. Hopper, M. Yeates, P. Sambrook, S. Eberl (1987)
Genetic determinants of bone mass in adults. A twin study.The Journal of clinical investigation, 80 3
N. Ota, S. Hunt, T. Nakajima, Takao Suzuki, T. Hosoi, H. Orimo, Y. Shirai, M. Emi (2000)
Linkage of human tumor necrosis factor-alpha to human osteoporosis by sib-pair analysisGenes and Immunity, 1
R. Zee, R. Myers, M. Hannan, P. Wilson, J. Ordovás, E. Schaefer, K. Lindpaintner, D. Kiel (2000)
Absence of Linkage for Bone Mineral Density to Chromosome 12q12-14 in the Region of the Vitamin D Receptor GeneCalcified Tissue International, 67
J. Christian, P. Yu, C. Slemenda, C. Johnston (1989)
Heritability of bone mass: a longitudinal study in aging male twins.American journal of human genetics, 44 3
(2000)
Genome scans for quantitative trait loci using variance component linkage analysis: upward bias in heritability estimates attributable to individual quantitative trait loci at lod-score peaks
A. Looker, E. Orwoll, C. Johnston, R. Lindsay, H. Wahner, W. Dunn, M. Calvo, T. Harris, S. Heyse (1997)
Prevalence of Low Femoral Bone Density in Older U.S. Adults from NHANES IIIJournal of Bone and Mineral Research, 12
M. Mahaney, J. Blangero, Anthony Comuzzie, J. VandeBerg, M. Stern, J. Maccluer (1995)
Plasma HDL cholesterol, triglycerides, and adiposity. A quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study.Circulation, 92 11
L. Almasy, J. Blangero (1998)
Multipoint quantitative-trait linkage analysis in general pedigrees.American journal of human genetics, 62 5
N. Ray, Julien Chan, M. Thamer, L. Melton (1997)
Medical Expenditures for the Treatment of Osteoporotic Fractures in the United States in 1995: Report from the National Osteoporosis FoundationJournal of Bone and Mineral Research, 12
P. Kelly, Tuan Nguyen, J. Hopper, N. Pocock, P. Sambrook, J. Eisman (1993)
Changes in axial bone density with age: A twin studyJournal of Bone and Mineral Research, 8
Daniel Koller, L. Rodriguez, J. Christian, C. Slemenda, Michael Econs, S. Hui, P. Morin, P. Conneally, G. Joslyn, M. Curran, M. Peacock, C. Johnston, T. Foroud (1998)
Linkage of a QTL Contributing to Normal Variation in Bone Mineral Density to Chromosome 11q12–13Journal of Bone and Mineral Research, 13
E. Seeman, J. Hopper, L. Bach, Mark Cooper, E. Parkinson, J. Mckay, G. Jerums (1989)
Reduced bone mass in daughters of women with osteoporosis.The New England journal of medicine, 320 9
T. Niu, Changzhong Chen, H. Cordell, Jianhua Yang, Bin-yan Wang, Zhaoxi Wang, Z. Fang, N. Schork, C. Rosen, Xiping Xu (1999)
A genome-wide scan for loci linked to forearm bone mineral densityHuman Genetics, 104
G. Livshits, O. Pavlovsky, E. Kobyliansky (1996)
Population biology of human aging: segregation analysis of bone age characteristics.Human biology, 68 4
Osteoporosis is a common condition characterized by reduced skeletal strength and increased susceptibility to fracture. Eight million Americans over the age of 50 have osteoporosis of the femoral neck. The most important risk factor for osteoporosis is low bone mineral density (BMD), and several epidemiological studies have shown the importance of genetic factors in determining variability of BMD. An initial genome screen in seven large pedigrees suggested that a candidate region conferring susceptibility to low BMD of the femoral neck was located on chromosome 1p36. We have now confirmed and extended this finding by analyzing nine microsatellite markers spanning a 40 cM interval across the candidate region in an expanded sample of 42 families. Heritability of femoral neck BMD was estimated as 0.51 ± 0.13 in these families, after accounting for the effects of age, sex, body mass index, height and weight. Variance component linkage analysis yielded a maximum multipoint LOD score of 3.53 for linkage of femoral neck BMD to a quantitative trait locus (QTL) located near marker D1S214. The associated empirical P -value by simulation analysis was equal to 0.0001. The results strongly support the hypothesis that a major QTL controlling femoral neck BMD is located on chromosome 1p36.2–p36.3, and further analysis of candidate genes in this region is warranted. Received June 29, 2001; Revised and Accepted August 13, 2001. « Previous | Next Article » Table of Contents This Article Hum. Mol. Genet. (2001) 10 (21): 2447-2452. doi: 10.1093/hmg/10.21.2447 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Report Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Devoto, M. Articles by Spotila, L. D. Search for related content PubMed PubMed citation Articles by Devoto, M. Articles by Specchia, C. Articles by Li, H. H. Articles by Caminis, J. Articles by Tenenhouse, A. Articles by Rodriguez, H. Articles by Spotila, L. D. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 15, 2015 24 (22) Alert me to new issues The Journal About this journal Rights & Permissions Dispatch date of the next issue This journal is a member of the Committee on Publication Ethics (COPE) We are mobile – find out more Journals Career Network Impact factor: 6.393 5-Yr impact factor: 6.850 Executive Editors Professor Kay Davies Professor Anthony Wynshaw-Boris Professor Joel Hirschhorn Dr Jeffrey Barrett View full editorial board For Authors Instructions to authors Online submission Submit Now! Self-archiving policy Open access options for authors - visit Oxford Open This journal enables compliance with the NIH Public Access Policy Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("SCI01140"); Most Most Read Genetics of obesity and the prediction of risk for health Non-coding RNA Telomerase and cancer Ion channel diseases Down syndrome--recent progress and future prospects » View all Most Read articles Most Cited The DNA methyltransferases of mammals Nonsense-Mediated mRNA Decay in Health and Disease Mutation of human short tandem repeats Prediction of deleterious human alleles Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1460-2083 - Print ISSN 0964-6906 Copyright © 2015 Oxford University Press Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-16"); pageTracker._setDomainName(".oxfordjournals.org"); pageTracker._trackPageview(); } catch(err) {}
Human Molecular Genetics – Oxford University Press
Published: Oct 2, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.