The implications of aspirin resistance in renal failure
Abstract
192 2. Hurst FP, Bohen EM, Osgard EM et al. Association of oral sodium phosphate purgative use with acute kidney injury. J Am Soc Nephrol 2007; 18: 3192â3198 3. Chan A, Depew W, Vanner S. Use of oral sodium phosphate colonic lavage solution by Canadian colonoscopists: pitfalls and complications. Can J Gastroenterol 1997; 11: 334â338 doi: 10.1093/ndtplus/sfn020 NDT Plus (2008) 3: 192 Advance Access publication 27 March 2008 The implications of aspirin resistance in renal failure Sir, Aspirin resistance is a phenomenon where the expected inhibition of platelet responses is not obtained as evaluated by different biological tests [1]. In addition to non-compliance and other patient-related factors, one of the main reasons for aspirin resistance is its inability to inhibit thromboxane A2 (TXA2 ) biosynthesis in vivo. Many studies have also shown that patients with aspirin resistance are more likely to have an increased rate of recurrence of vascular events [2,3]. Interestingly, in a recent systematic review by Krasopoulos et al., the relationship between resistance to aspirin and a history of renal impairment was observed (P < 0.03) [4]. This was considered as possibly a chance finding, mainly because of lack of substantial data. However, an abnormality of