SYNTHETIC SUBSTITUTES FOR ATROPINE
Abstract
REFBRSNCD Dodds, E. C . Lawson, W. & Williams, P. C. (1944) Proc. roy. foe. B, 131,119 Eddy, N. B. (1939) Amer. J. med. Set. 197, 464 Small, L. F., Eddy, N. B., Moscttig, E. & Himmelibach, C. K. (1938) Studies on drug addiction, Publ. Hlth Rtp., Wash. suppl. 138 chloride about 15 %. These results led to a systematic study of benzilic esters of the general formula : (CJI.),C(OH).COO(CH 1 )oNR R' R ' | x , where R, R' and R ' are alky] groups, X is a halide anion, and n = 2 or 3. Before discussing the results of this study, it may be well to outline briefly the method used to estimate mydriatic activity. FIG. I. FORMULAE OF ATROPINE AND SYNTHETIC SUBSTITUTES INVESTIGATED CH,OH CHj-CHâCH, CHCOOCH N H CH3 3 I I CHj-CH H. R. ING, M.A., D.Phil. Department ofPharmacology, Oxford During the war need arose to investigate synthetic mydriatics which might be used in place of atropine if supplies of the latter became inadequate. Synthetic atropine was thought to present a far too difficult manufacturing problem and the only synthetic mydriatic of the atropine type in common use, viz. eucatropine, is a