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Felsenfeld S, Broen Pa, Mcgue M, Johnson Cj, Beitchman Jh, Young Escobar, M. Atkinson, Wilson B, D. Robinson, Allison Smith, G. Johnston (2000)
Severity of overdose after restriction of paracetamol availability: retrospective studyBMJ : British Medical Journal, 321
Thomas Mr, Jowett Ni (2001)
Severity of overdose after restriction of paracetamol availability. Restriction has not reduced admissions with self poisoning.BMJ, 322 7285
(2002)
Deaths Related to Drug Poisoning: results for England and Wales, 1993 to 2000
E. Norman, R. Dhairiwan, P. Dargan, Craig Wallace, A. Jones (2001)
Paracetamol poisoning: can it be prevented?
(1998)
Paracetamol and aspirin
P. Ott, K. Dalhoff, P. Hansen, S. Loft, H. Poulsen (1990)
Consumption, overdose and death from analgesics during a period of over‐the‐counter availability of paracetamol in DenmarkJournal of Internal Medicine, 227
D. Gunnell (2002)
Paracetamol recall: a natural experiment influencing analgesic poisoningMedical Journal of Australia, 176
R. Farmer (1992)
Epidemiology of SuicideInternational Clinical Psychopharmacology, 6
K. Hawton, Christopher Ware, H. Mistry, J. Hewitt, Stephen Kingsbury, D. Roberts, Heather Weitzel (1995)
Why patients choose paracetamol for self poisoning and their knowledge of its dangersBMJ, 310
(1996)
Analgesic medicines available without prescription: proposed changes to product information and sale of supply of paracetamol
Suzanne West, V. King, Timothy Carey, K. Lohr, N. McKoy, S. Sutton, Linda Lux (2002)
Systems to rate the strength of scientific evidence.Evidence report/technology assessment, 47
C. Sheen, J. Dillon, D. Bateman, K. Simpson, T. MacDonald (2002)
Paracetamol-related deaths in Scotland, 1994-2000.British journal of clinical pharmacology, 54 4
(2003)
28 Medicines and Healthcare Products Regulatory Agency. Consultation Arm 18: Reclassification summary for simvastatin POP to P
C. Sheen, J. Dillon, D. Bateman, K. Simpson, T. MacDonald (2001)
The effect on toxicity and healthcare cests on reducing the size of avallable acetaminophen pack sizes in the Tayside region of ScotlandGastroenterology, 120
(2003)
National Audit Office. Safety, quality, efficacy: regulating medicines in the UK. London: The Stationary Office
D. Gunnell, K. Hawton, V. Murray, R. Garnier, C. Bismuth, J. Fagg, S. Simkin (1997)
Use of paracetamol for suicide and non-fatal poisoning in the UK and France: are restrictions on availability justified?Journal of Epidemiology and Community Health, 51
K. Hawton, Christopher Ware, H. Mistry, J. Hewitt, Stephen Kingsbury, D. Roberts, Heather Weitzel (1996)
Paracetamol Self-Poisoning Characteristics, Prevention and Harm ReductionBritish Journal of Psychiatry, 168
(2001)
Restrictions on sale of paracetamol in Ireland had no impact on the number of tablets ingested in acute deliberate overdose
Z. Kmietowicz (2003)
Medicines Control Agency must be more openBMJ : British Medical Journal, 326
B. Hughes, A. Durran, N. Langford, D. Mutimer (2003)
Paracetamol poisoning – impact of pack size restrictionsJournal of Clinical Pharmacy and Therapeutics, 28
RJ Flanagan, C. Rooney, robert. flanagan (2002)
Recording acute poisoning deaths.Forensic science international, 128 1-2
C. Sheen, J. Dillon, D. Bateman, K. Simpson, T. MacDonald (2002)
Paracetamol pack size restriction: the impact on paracetamol poisoning and the over‐the‐counter supply of paracetamol, aspirin and ibuprofenPharmacoepidemiology and Drug Safety, 11
J. Turvill, A. Burroughs, K. Moore (2000)
Change in occurrence of paracetamol overdose in UK after introduction of blister packsThe Lancet, 355
N. Kreitman (1976)
The coal gas story. United Kingdom suicide rates, 1960-71.British Journal of Preventive & Social Medicine, 30
M. Prince, Simon Thomas, O. James, M. Hudson (2000)
Reduction in incidence of severe paracetamol poisoningThe Lancet, 355
(2001)
Have the new pack size regulations impacted on UK paracetamol overdose
C. Sheen, T. MacDonald (2001)
Severity of overdose after restriction of paracetamol availabilityBMJ : British Medical Journal, 322
K. Hawton, E. Townsend, J. Deeks, L. Appleby, D. Gunnell, Olive Bennewith, J. Cooper (2001)
Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after studyBMJ : British Medical Journal, 322
D. Bateman, M. Bain, D. Gorman, D. Murphy (2003)
Changes in paracetamol, antidepressants and opioid poisoning in Scotland during the 1990s.QJM : monthly journal of the Association of Physicians, 96 2
Background Paracetamol poisoning is implicated in about 150–200 poisoning deaths per year in England and Wales. We review previous studies assessing the effectiveness of regulations introduced in 1998 to restrict sales of paracetamol and reduce paracetamol poisoning.Methods We searched the following electronic databases: MEDLINE, EMBASE, CINHAL, HIMIC, COCH, APC, CENTRAL and DARE. English language publications between 1998 and 2003 were included. Studies were included if they took place in the United Kingdom and assessed changes in any aspect of paracetamol poisoning following the introduction of the 1998 regulations.Results Twelve studies were identified, which examined several different outcomes. Three studies examined admissions to liver transplant units; all reported reductions. Eight studies evaluated severity of paracetamol poisoning; three reported reductions but five did not. Five out of six studies reported reductions in hospital admissions. One study reported reduced mortality in England and Wales after 1 year while another found no difference in Scotland 2 years after the regulations were introduced. Two studies observed a significant reduction in over-the-counter sales. Studies suffered from several limitations including short follow-up periods, no case definition for paracetamol poisoning and lack of comparison groups.Conclusions The limitations of these studies makes it difficult to draw firm conclusions. They do, however, suggest that the 1998 regulations may have been associated with reduced admissions to liver units and liver transplants, reduced hospital attendance due to paracetamol poisoning and reduced sales of paracetamol. Further research is needed to fully evaluate the impact of the 1998 regulations. In the future, formal evaluation of the impact of similar interventions should be an integral part of policy formation.
Journal of Public Health – Oxford University Press
Published: Mar 8, 2005
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