“Woah! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free




Department of Chemical Pathology Guy's Hospital Medical School, London Vaccination against exoerythrocytic stages a Sporozoite vaccines b Antigens of sporozoites Vaccination against blood-stage parasites a Merozoite vaccines b Antigens of blood-stage parasites Vaccination against sexual forms Concluding remarks References a variety of methods (reviewed by Cohen & Mitchell, 1978). During recent years, attempts at experimental vaccination have focused mainly on the use of extracellular stages of the parasite le-cycle—particularly sporozoites, erythrocytic merozoites and microgametes; the present discussion will be confined to these forms of malaria vaccine. Vaccination against Exoerythrocytic Stages The pattern of acquired immunity to malaria infection varies widely in dferent host-parasite combinations. In some instances, for example, Plasmodium knowlesi in the rhesus monkey, the immune response is clinically ineffective and the disease rapidly fatal. Other forms of experimental malaria, e.g. P. berghei in the rat, induce "sterilizing" immunity characterized by complete elimination of the parasite and lelong resistance to challenge. In the case of naturally occurring infections, acquired immunity usually controls but does not eliminate the parasite, which persists at low density over long periods. This is characteristic of the human malarias. Thus, the inhabitants of hyperendemic areas show a consistent pattern of susceptibility and resistance
Loading next page...
Problems Reading this Article? Report Issue Here

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for only $40/month.

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.