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IMMUNOLOGICAL AND INFLAMMATORY DISORDERS OF THE CENTRAL NERVOUS SYSTEM.

IMMUNOLOGICAL AND INFLAMMATORY DISORDERS OF THE CENTRAL NERVOUS SYSTEM. Book reviews Brain (1999), 122, 2195–2200 IMMUNOLOGICAL AND INFLAMMATORY between immunologists and neurologists. The section on cerebral vasculitis provides fascinating reading on this very DISORDERS OF THE CENTRAL NERVOUS SYSTEM. heterogeneous group of disorders by focusing on vasculitis Edited by N. Scolding. that affects mainly the cerebral vessels. Nevertheless, a 1999. Oxford: Butterworth-Heinemann. classification and short descriptions of virtually all vasculitic Price £45.00. Pp. 264. syndromes are given, and here Scolding’s own achievement ISBN 0-7506-2357-8. is considerable: the survey of classification, diagnosis and Our growing knowledge of fundamental immunological management of cerebral vasculitis given here are extremely mechanisms in the central nervous system, and consequently valuable and helpful for the reader. the therapeutic options for these diseases, reflects the Another interesting chapter to be highly recommended to importance of the book Immunological and inflammatory the reader is dedicated to paraneoplastic disorders of the disorders of the central nervous system. It is essential reading central nervous system. Knowledge of the neurological for the neurologist as well as the experimental immunologist symptoms and associated antibodies can lead to the detection interested in autoimmune reactions to neural elements. of an occult malignancy. After depicting a somewhat ironic view of neuro- The book contains three additional concise chapters: one on immunology in the Preface, Neil Scolding provides an sarcoidosis of the CNS; one on organ-specific autoimmune impressive overview of the most important diseases affecting diseases with involvement of the CNS (e.g. autoimmune dis- the central nervous system via inflammatory and eases of the bowel and thyroid); and finally one on the clinical immunological mechanisms. The clinical, pathophysiological and immunological features of the ‘Stiff man syndrome’. and therapeutic aspects of these disorders are thoroughly Scolding proposes with tongue in cheek that it should be covered. Only disorders of peripheral nerves and muscles are renamed the ‘Moersch–Woltperson syndrome’, so as not to not included. The 10 chapters of the book have been mainly exclude women from the diagnosis. written by the editor himself, thus ensuring a consistent style Overall, this is a valuable reference book for clinicians and and the avoidance of redundancy. experimental immunologists involved in the diagnosis and After a short general introduction to the immune responses treatment of neuroimmunological disorders. The illustrations and their relation to the nervous system, the next three are, in general, well chosen, although the reproduction of some chapters are dedicated to multiple sclerosis, related disorders, figures (Histology, MRI) suffers somewhat from the paper and current and future therapies for multiple sclerosis. The quality and the absence of colour. All chapters are well refer- multiple sclerosis chapters not only provide clinical, enced with key articles, generally published between 1997 epidemiological and diagnostic outlines, but also a well- and 1998. substantiated summary of current knowledge about the A few suggestions for the next edition: the index should be pathogenesis of inflammatory demyelination. The syndromes extended, and the headings or subheadings could be arranged and disorders related to multiple sclerosis are discussed in a more clearly to facilitate quick searching, a prerequisite for the separate chapter. This subdivision helps the clinician to stressed clinician. A chapter on the immunological aspects of distinguish between classic multiple sclerosis, historically epilepsy (e.g. on Rasmussen’s encephalitis) would also be associated variants, different disease courses and distinct worthwhile considering. clinical entities. The impact of our growing understanding Despite such minor points of criticism, the authors are to of multiple sclerosis pathogenesis on therapeutic strategies be congratulated on their admirable achievement. This well- is succinctly summed up in the next chapter, entitled ‘Current structured and balanced account of our current knowledge of and future therapies for multiple sclerosis’. As Scolding the clinical and basic scientific aspects of inflammatory and mentions in his Preface, the ‘historical’ approach that immunological CNS disorders will appeal to clinicians, differentiated neurological diseases into steroid-responsive students and researchers alike. and steroid-unresponsive cases seems to come from another H. Wiendl age in the light of today’s numerous treatment strategies. Max-Planck Institute for Neurobiology, The chapter on ‘Neurological complications of rheumato- Department of Neuroimmunology, logical and connective tissue disorders’ is one of the most Martinsried, Germany important in this book, especially in view of their prevalence today. Most of the emphasis is on the description of different R. Hohlfeld aspects of systemic lupus erythematosus and the neurological Institute for Clinical Neuroimmunology, implications. The sections on therapy for the underlying Ludwig-Maximilians-University, diseases are less extensive than in the multiple sclerosis chapter. Mu ¨ nchen, Germany The book succeeds in depicting the overlap and ‘crosstalk’ © Oxford University Press 1999 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Oxford University Press

IMMUNOLOGICAL AND INFLAMMATORY DISORDERS OF THE CENTRAL NERVOUS SYSTEM.

Wiendl, H.
Brain , Volume 122 (11) – Nov 1, 1999
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Publisher
Oxford University Press
Copyright
Copyright 1999
ISSN
0006-8950
eISSN
1460-2156
DOI
10.1093/brain/122.11.2195
Publisher site
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Abstract

Book reviews Brain (1999), 122, 2195–2200 IMMUNOLOGICAL AND INFLAMMATORY between immunologists and neurologists. The section on cerebral vasculitis provides fascinating reading on this very DISORDERS OF THE CENTRAL NERVOUS SYSTEM. heterogeneous group of disorders by focusing on vasculitis Edited by N. Scolding. that affects mainly the cerebral vessels. Nevertheless, a 1999. Oxford: Butterworth-Heinemann. classification and short descriptions of virtually all vasculitic Price £45.00. Pp. 264. syndromes are given, and here Scolding’s own achievement ISBN 0-7506-2357-8. is considerable: the survey of classification, diagnosis and Our growing knowledge of fundamental immunological management of cerebral vasculitis given here are extremely mechanisms in the central nervous system, and consequently valuable and helpful for the reader. the therapeutic options for these diseases, reflects the Another interesting chapter to be highly recommended to importance of the book Immunological and inflammatory the reader is dedicated to paraneoplastic disorders of the disorders of the central nervous system. It is essential reading central nervous system. Knowledge of the neurological for the neurologist as well as the experimental immunologist symptoms and associated antibodies can lead to the detection interested in autoimmune reactions to neural elements. of an occult malignancy. After depicting a somewhat ironic view of neuro- The book contains three additional concise chapters: one on immunology in the Preface, Neil Scolding provides an sarcoidosis of the CNS; one on organ-specific autoimmune impressive overview of the most important diseases affecting diseases with involvement of the CNS (e.g. autoimmune dis- the central nervous system via inflammatory and eases of the bowel and thyroid); and finally one on the clinical immunological mechanisms. The clinical, pathophysiological and immunological features of the ‘Stiff man syndrome’. and therapeutic aspects of these disorders are thoroughly Scolding proposes with tongue in cheek that it should be covered. Only disorders of peripheral nerves and muscles are renamed the ‘Moersch–Woltperson syndrome’, so as not to not included. The 10 chapters of the book have been mainly exclude women from the diagnosis. written by the editor himself, thus ensuring a consistent style Overall, this is a valuable reference book for clinicians and and the avoidance of redundancy. experimental immunologists involved in the diagnosis and After a short general introduction to the immune responses treatment of neuroimmunological disorders. The illustrations and their relation to the nervous system, the next three are, in general, well chosen, although the reproduction of some chapters are dedicated to multiple sclerosis, related disorders, figures (Histology, MRI) suffers somewhat from the paper and current and future therapies for multiple sclerosis. The quality and the absence of colour. All chapters are well refer- multiple sclerosis chapters not only provide clinical, enced with key articles, generally published between 1997 epidemiological and diagnostic outlines, but also a well- and 1998. substantiated summary of current knowledge about the A few suggestions for the next edition: the index should be pathogenesis of inflammatory demyelination. The syndromes extended, and the headings or subheadings could be arranged and disorders related to multiple sclerosis are discussed in a more clearly to facilitate quick searching, a prerequisite for the separate chapter. This subdivision helps the clinician to stressed clinician. A chapter on the immunological aspects of distinguish between classic multiple sclerosis, historically epilepsy (e.g. on Rasmussen’s encephalitis) would also be associated variants, different disease courses and distinct worthwhile considering. clinical entities. The impact of our growing understanding Despite such minor points of criticism, the authors are to of multiple sclerosis pathogenesis on therapeutic strategies be congratulated on their admirable achievement. This well- is succinctly summed up in the next chapter, entitled ‘Current structured and balanced account of our current knowledge of and future therapies for multiple sclerosis’. As Scolding the clinical and basic scientific aspects of inflammatory and mentions in his Preface, the ‘historical’ approach that immunological CNS disorders will appeal to clinicians, differentiated neurological diseases into steroid-responsive students and researchers alike. and steroid-unresponsive cases seems to come from another H. Wiendl age in the light of today’s numerous treatment strategies. Max-Planck Institute for Neurobiology, The chapter on ‘Neurological complications of rheumato- Department of Neuroimmunology, logical and connective tissue disorders’ is one of the most Martinsried, Germany important in this book, especially in view of their prevalence today. Most of the emphasis is on the description of different R. Hohlfeld aspects of systemic lupus erythematosus and the neurological Institute for Clinical Neuroimmunology, implications. The sections on therapy for the underlying Ludwig-Maximilians-University, diseases are less extensive than in the multiple sclerosis chapter. Mu ¨ nchen, Germany The book succeeds in depicting the overlap and ‘crosstalk’ © Oxford University Press 1999

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Brain – Oxford University Press

Published: Nov 1, 1999

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