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HardyWeinberg Expectations in Canine Breeds: Implications for Genetic Studies

HardyWeinberg Expectations in Canine Breeds: Implications for Genetic Studies HardyWeinberg equilibrium (HWE) is a useful indicator of genotype frequencies within a population and whether they are based on a valid definition of alleles and a randomly mating sample. HWE assumes a stable population of adequate size without selective pressures and is used in human genetic studies as a guide to data quality by comparing observed genotype frequencies to those expected within a population. The calculation of genetic associations in casecontrol studies assume that the population is in HWE. Canine breed populations deviate away from many of the criteria for HWE, and if genetic markers are not in HWE, conventional statistical analysis cannot be performed. To date, little attention has been paid as to whether genetic markers in dog breeds are distributed in compliance to HWE. In this study, 109 single-nucleotide polymorphisms (SNPs) were genotyped from 13 genes in a cohort of 894 dogs encompassing 33 breeds. Analysis of the entire cohort of dogs revealed a significant deviation away from HWE for all SNPs tested (P < 0.00001); analysis of the cohort stratified by breed and subbreed indicated that the majority of the markers complied with HWE expectation. This suggests that canine casecontrol association studies will be valid if performed within defined breeds. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Heredity Oxford University Press

HardyWeinberg Expectations in Canine Breeds: Implications for Genetic Studies

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References (14)

Publisher
Oxford University Press
Copyright
The American Genetic Association. 2007. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
ISSN
0022-1503
eISSN
1465-7333
DOI
10.1093/jhered/esm020
pmid
17526918
Publisher site
See Article on Publisher Site

Abstract

HardyWeinberg equilibrium (HWE) is a useful indicator of genotype frequencies within a population and whether they are based on a valid definition of alleles and a randomly mating sample. HWE assumes a stable population of adequate size without selective pressures and is used in human genetic studies as a guide to data quality by comparing observed genotype frequencies to those expected within a population. The calculation of genetic associations in casecontrol studies assume that the population is in HWE. Canine breed populations deviate away from many of the criteria for HWE, and if genetic markers are not in HWE, conventional statistical analysis cannot be performed. To date, little attention has been paid as to whether genetic markers in dog breeds are distributed in compliance to HWE. In this study, 109 single-nucleotide polymorphisms (SNPs) were genotyped from 13 genes in a cohort of 894 dogs encompassing 33 breeds. Analysis of the entire cohort of dogs revealed a significant deviation away from HWE for all SNPs tested (P < 0.00001); analysis of the cohort stratified by breed and subbreed indicated that the majority of the markers complied with HWE expectation. This suggests that canine casecontrol association studies will be valid if performed within defined breeds.

Journal

Journal of HeredityOxford University Press

Published: May 26, 2007

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