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- Publisher
- Oxford University Press
- Copyright
- The Author [2011]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
- ISSN
- 0142-6338
- eISSN
- 1465-3664
- DOI
- 10.1093/tropej/fmr015
- pmid
- 21321006
- Publisher site
- See Article on Publisher Site
Abstract
Background: Maternal alcohol abuse during pregnancy can lead to fetal neurotoxicity and fetal alcohol spectrum disorder (FASD). Aims: To compare the clinical features and neurobehavioral profiles of children exposed to alcohol during pregnancy with controls. Methodology: Children exposed to alcohol in utero (n26) and 27-years age- and sex-matched controls were compared on FAS facial features, minor physical anomalies (MPAs), anthropometric measures, behavioral problems and intellectual functioning. Results: MPAs were more common in cases (p0.001). Among FAS facial features, only philtrum smoothness varied significantly between the groups (p0.001). Behavioral problems (on Childhood Behavior Check List) were more pronounced (p0.001) and intellectual functioning significantly poorer in cases (p0.001) compared to controls. Conclusions: Children prenatally exposed to alcohol manifest several neurobehavioral problems compared to controls. Underlying malnutrition may have altered some of the clinical findings.
Journal
Journal of Tropical Pediatrics – Oxford University Press
Published: Feb 14, 2012
Keywords: prenatal alcohol exposure fetal alcohol spectrum disorders fetal alcohol syndrome intellectual dysfunction behavioral problems