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False-positive extended-spectrum β-lactamase tests for Klebsiella oxytoca strains hyperproducing K1 β-lactamase

False-positive extended-spectrum β-lactamase tests for Klebsiella oxytoca strains hyperproducing... Correspondence ParC proteins. The results show that the use of 20 mg/L of Phe-Arg- References β-naphthylamide decreased the MIC of nalidixic acid (from two to 1. Everett, M. J., Fang Jin, Y., Ricci, V. et al. (1996). Contributions of five serial two-fold dilution steps) in all isolates tested, even in those individual mechanisms to fluoroquinolone resistance in 36 Escherichia with the nalidixic acid-susceptible phenotype. This high reduction in coli strains isolated from humans and animals. Antimicrobial Agents and the MIC values was observed independent of the number of amino Chemotherapy 40, 2380–6. acid changes in GyrA and ParC. This effect was especially noticeable 2. Lomovskaya, O., Warren, M. S., Lee, A. et al. (2001). Identification among isolates carrying one single GyrA substitution, in which the and characterization of inhibitors of multidrug resistance efflux pumps in MIC of nalidixic acid decreased from resistant to susceptible levels Pseudomonas aeruginosa: novel agents for combination therapy. Anti- (from 128 to 8 mg/L). This result indicates that one amino acid change microbial Agents and Chemotherapy 45, 105–16. in GyrA by itself (without an additional mechanism of resistance) is 3. Malléa, M., Mahamoud, A., Chevalier, J. et al. (2003). Alkylamino- unable to confer a resistant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Antimicrobial Chemotherapy Oxford University Press

False-positive extended-spectrum β-lactamase tests for Klebsiella oxytoca strains hyperproducing K1 β-lactamase

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References (5)

Publisher
Oxford University Press
Copyright
The British Society for Antimicrobial Chemotherapy
ISSN
0305-7453
eISSN
1460-2091
DOI
10.1093/jac/dkh112
pmid
14963067
Publisher site
See Article on Publisher Site

Abstract

Correspondence ParC proteins. The results show that the use of 20 mg/L of Phe-Arg- References β-naphthylamide decreased the MIC of nalidixic acid (from two to 1. Everett, M. J., Fang Jin, Y., Ricci, V. et al. (1996). Contributions of five serial two-fold dilution steps) in all isolates tested, even in those individual mechanisms to fluoroquinolone resistance in 36 Escherichia with the nalidixic acid-susceptible phenotype. This high reduction in coli strains isolated from humans and animals. Antimicrobial Agents and the MIC values was observed independent of the number of amino Chemotherapy 40, 2380–6. acid changes in GyrA and ParC. This effect was especially noticeable 2. Lomovskaya, O., Warren, M. S., Lee, A. et al. (2001). Identification among isolates carrying one single GyrA substitution, in which the and characterization of inhibitors of multidrug resistance efflux pumps in MIC of nalidixic acid decreased from resistant to susceptible levels Pseudomonas aeruginosa: novel agents for combination therapy. Anti- (from 128 to 8 mg/L). This result indicates that one amino acid change microbial Agents and Chemotherapy 45, 105–16. in GyrA by itself (without an additional mechanism of resistance) is 3. Malléa, M., Mahamoud, A., Chevalier, J. et al. (2003). Alkylamino- unable to confer a resistant

Journal

Journal of Antimicrobial ChemotherapyOxford University Press

Published: Mar 1, 2004

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