Subscribe to thousands of academic journals for just $40/month
Read and share the articles you need for your research, all in one place.

Endoscopic Sphincterotomy and Long-Term Risk of Cholangiocarcinoma: A Population-Based Follow-up Study

JNCI: Journal of the National Cancer Institute , Volume 100 (10) – May 1, 2008

Details

Publisher
Oxford University Press
Copyright
Copyright © Oxford University Press
ISSN
0027-8874
eISSN
1460-2105
D.O.I.
10.1093/jnci/djn102
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Endoscopic Sphincterotomy and Long-Term Risk of Cholangiocarcinoma: A Population-Based Follow-up Study

Abstract

Sphincterotomy of the ampulla of Vater—a common diagnostic and therapeutic procedure that is sometimes done during endoscopic retrograde cholangiography (ERC)—allows reflux of intestinal content into the biliary tree. The resulting inflammation may contribute to malignant transformation of the biliary epithelium and therefore increase the risk of cholangiocarcinoma. We used data from population-based Danish health-care registries to examine the incidence of cholangiocarcinoma after ERC for 10 690 ERC patients who underwent sphincterotomy between 1977 and 2003 and 10 690 ERC patients who did not undergo sphincterotomy. Patients with sphincterotomy were matched to patients without sphincterotomy by sex and age at, calendar year of, and indication for ERC. The cholangiocarcinoma incidence rate for sphincterotomy patients was 404 per 100 000 person-years during the first year after ERC and decreased progressively at later times after ERC (79, 42, and 27 per 100 000 person-years during years 2, 3–5, and >5, respectively). The corresponding rates for patients without sphincterotomy were 458, 12, 10, and 19 per 100 000 person-years, respectively. The gradual decrease in cholangiocarcinoma rate over time after ERC for sphincterotomy patients indicates that some of these patients had a cholangiocarcinoma that was present at the time of ERC but not diagnosed until 2–5 years later. The similar rates at the latest times after ERC suggest the lack of a causal association between sphincterotomy and cholangiocarcinoma.
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.

 
/lp/oxford-university-press/endoscopic-sphincterotomy-and-long-term-risk-of-cholangiocarcinoma-a-MuiTkWSEG2