Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Manocha, P. Mediratta, K. Sharma (2003)
Studies on the anticonvulsant effect of U50488H on maximal electroshock seizure in micePharmacology Biochemistry and Behavior, 76
R. Jones, P. Portoghese (2000)
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.European journal of pharmacology, 396 1
A. Mansour, C. Fox, F. Meng, H. Akil, S. Watson (1994)
Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA.Molecular and cellular neurosciences, 5 2
(2005)
WHO Atlas: epilepsy care in the world Geneva: Programme for Neurological Diseases and Neuroscience, Department of Mental Health and Substance Abuse
Peng Xia, G. Pei, W. Schwarz (2006)
Regulation of the glutamate transporter EAAC1 by expression and activation of δ‐opioid receptorEuropean Journal of Neuroscience, 24
H. Yokoyama, K. Onodera, T. Suzuki, K. Iinuma, T. Watanabe (1992)
Opioid mu-deficient CXBK mouse and the role of mu 1-receptors in electrically induced convulsions.Brain research, 595 1
A. DePaoli, K. Hurley, Kazuki Yasada, T. Reisine, G. Bell (1994)
Distribution of κ Opioid Receptor mRNA in Adult Mouse Brain: An in Situ Hybridization Histochemistry StudyMolecular and Cellular Neuroscience, 5
M. JonesRobert, P. Portoghese (2000)
5'-Guanidinonaltrindole, a highly selective and potent κ-opioid receptor antagonistEuropean Journal of Pharmacology, 396
(2007)
Page 12 of 12 Brain
K. Franklin, G. Paxinos (2001)
The Mouse Brain in Stereotaxic Coordinates
C. Drake, G. Terman, M. Simmons, T. Milner, D. Kunkel, P. Schwartzkroin, C. Chavkin (1994)
Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters, 14
Shu Lin, Dana Boey, N. Lee, C. Schwarzer, A. Sainsbury, H. Herzog (2006)
Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brainNeuropeptides, 40
R. Maggi, P. Limonta, D. Dondi, L. Martini, F. Piva (1989)
Distribution of kappa opioid receptors in the brain of young and old male rats.Life sciences, 45 22
S. Khavandgar, H. Homayoun, A. Dehpour (2002)
The role of nitric oxide in the proconvulsant effect of delta-opioid agonist SNC80 in mice.Neuroscience letters, 329 2
V. Descamps, S. Collot, N. Houhou, S. Ranger-Rogez (2003)
Prodynorphin gene promoter polymorphism and temporal lobe epilepsyAnnals of Neurology, 53
D. Jewett, M. Grace, Robert Jones, C. Billington, P. Portoghese, A. Levine (2001)
The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in ratsBrain Research, 909
C. Schwarzer, U. Berresheim, S. Pirker, A. Wieselthaler, K. Fuchs, W. Sieghart, G. Sperk (2001)
Distribution of the major γ‐aminobutyric acidA receptor subunits in the basal ganglia and associated limbic brain areas of the adult ratJournal of Comparative Neurology, 433
V. Bouilleret, V. Bouilleret, V. Ridoux, A. Depaulis, C. Marescaux, A. Nehlig (1999)
Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsyNeuroscience, 89
S. Henriksen, G. Chouvet, J. McGinty, F. Bloom (1982)
OPIOID PEPTIDES IN THE HIPPOCAMPUS: ANATOMICAL AND PHYSIOLOGICAL CONSIDERATIONS *Annals of the New York Academy of Sciences, 398
K. Nilsen, Hannah Cock (2004)
Focal treatment for refractory epilepsy: hope for the future?Brain Research Reviews, 44
M. Solbrig, Russell Adrian, J. Baratta, J. Lauterborn, G. Koob (2006)
Kappa opioid control of seizures produced by a virus in an animal model.Brain : a journal of neurology, 129 Pt 3
Scott Moore, S. Madamba, P. Schweitzer, G. Siggins (1994)
Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro, 14
C. Remy, S. Remy, H. Beck, D. Swandulla, M. Hans (2004)
Modulation of voltage-dependent sodium channels by the δ-agonist SNC80 in acutely isolated rat hippocampal neuronsNeuropharmacology, 47
G. Terman, C. Drake, M. Simmons, T. Milner, C. Chavkin (2000)
Opioid Modulation of Recurrent Excitation in the Hippocampal Dentate GyrusThe Journal of Neuroscience, 20
K. Rusin, D. Giovannucci, E. Stuenkel, H. Moises (1997)
κ-Opioid Receptor Activation Modulates Ca2+Currents and Secretion in Isolated Neuroendocrine Nerve TerminalsThe Journal of Neuroscience, 17
C. Chavkin, I. James, A. Goldstein (1982)
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.Science, 215 4531
A. Woods, R. Kaminski, M. Oz, Yun Wang, K. Hauser, R. Goody, Hay-Yan Wang, S. Jackson, P. Zeitz, K. Zeitz, D. Żółkowska, R. Schepers, Michael Nold, Jens Danielson, A. Gräslund, V. Vukojević, G. Bakalkin, A. Basbaum, T. Shippenberg (2006)
Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity.Journal of proteome research, 5 4
S. Clarke, A. Zimmer, A. Zimmer, R. Hill, I. Kitchen (2003)
Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice.Neuroscience, 122 2
Gambardella (2003)
Prodynorphin gene promoter polymorphism and temporal lobe epilepsyEpilepsia, 44
C. Polkey (2004)
Clinical outcome of epilepsy surgeryCurrent Opinion in Neurology, 17
P. Kwan, Josemir Sander (2004)
The natural history of epilepsy: an epidemiological viewJournal of Neurology, Neurosurgery & Psychiatry, 75
H. Yokoyama, K. Onodera, T. Suzuki, K. Iinuma, T. Watanabe (1992)
Opioid μ-deficient CXBK mouse and the role of μ 1-receptors in electrically induced convulsionsBrain Research, 595
J. Wagner, G. Terman, C. Chavkin (1993)
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampusNature, 363
R. Caudle, L. Isaac (1988)
A novel interaction between dynorphin(1–13) and an N-methyl-d-aspartate siteBrain Research, 443
J. Froehlich (1997)
Opioid PeptidesAlcohol Health and Research World, 21
A. Mansour, C. Fox, F. Meng, H. Akil, S. Watson (1994)
κ1 Receptor mRNA Distribution in the Rat CNS: Comparison to κ Receptor Binding and Prodynorphin mRNAMolecular and Cellular Neuroscience, 5
V. Shukla, J. Prasad, S. Lemaire (1997)
Nonopioid motor effects of dynorphin A and related peptides: structure dependence and role of the N-methyl-D-aspartate receptor.The Journal of pharmacology and experimental therapeutics, 283 2
F. Tortella, J. Long (1988)
Characterization of opioid peptide-like anticonvulsant activity in rat cerebrospinal fluidBrain Research, 456
T. Kai, H. Onishi, S. Koide, M. Katayama, S. Yamagami (1998)
Developmental and Regional Alteration of κ-Opioid Receptors in Seizure-Susceptible EL Mouse BrainNeurochemical Research, 23
D. Thompson, Z. Arzoumanian, D. Bertsch, K. Brazier, N. D'Amico, C. Fichtel, J. Fierro, R. Hartman, S. Hunter, S. Johnston, G. Kanbach, V. Kaspi, D. Kniffen, Y. Lin, A. Lyne, R. Manchester, J. Mattox, H. Mayer-Hasselwander, P. Michelson, C. Montigny, H. Nel, D. Nice, P. Nolan, K. Pinkau, H. Rothermel, E. Schneid, M. Sommer, P. Sreekumar, J. Taylor (1993)
Pulsed high-energy γ-rays from the radio pulsar PSR170644Nature, 365
A. Mcquiston, P. Saggau (2003)
Mu-opioid receptors facilitate the propagation of excitatory activity in rat hippocampal area CA1 by disinhibition of all anatomical layers.Journal of neurophysiology, 90 3
I. Aradi, V. Santhakumar, Kang Chen, I. Soltesz (2002)
Postsynaptic effects of GABAergic synaptic diversity: regulation of neuronal excitability by changes in IPSC varianceNeuropharmacology, 43
M. Solbrig, G. Koob (2004)
Epilepsy, CNS viral injury and dynorphin.Trends in pharmacological sciences, 25 2
F. Tortella (1988)
Endogenous opioid peptides and epilepsy: quieting the seizing brain?Trends in pharmacological sciences, 9 10
B. Rácz, K. Halasy (2002)
Kappa opioid receptor is expressed by somatostatin- and neuropeptide Y-containing interneurons in the rat hippocampusBrain Research, 931
S. Gackenheimer, T. Suter, J. Pintar, S. Quimby, W. Wheeler, C. Mitch, D. Gehlert, M. Statnick (2005)
Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sitesNeuropeptides, 39
M. Weisskopf, R. Zalutsky, R. Nicoll (1993)
The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiationNature, 362
C. Drake, T. Milner (2002)
Mu opioid receptors are in discrete hippocampal interneuron subpopulationsHippocampus, 12
C. Schwarzer, G. Sperk, C. Rauca, W. Pohle (1996)
Neuropeptide Y and somatostatin immunoreactivity in the rat hippocampus after moderate hypoxiaNaunyn-Schmiedeberg's Archives of Pharmacology, 354
J. McNamara (1999)
Emerging insights into the genesis of epilepsyNature, 399
M. Wollemann, S. Benyhe (2004)
Non-opioid actions of opioid peptides.Life sciences, 75 3
G. Cavalleri, J. Lynch, C. Depondt, M. Burley, N. Wood, S. Sisodiya, D. Goldstein (2005)
Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: where to from here?Brain : a journal of neurology, 128 Pt 8
Patrick Kwan, M. Brodie, M. Brodie (2000)
Early identification of refractory epilepsy.The New England journal of medicine, 342 5
F. Contamin (1954)
[Temporal lobe epilepsy].La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 30 24
G. Siggins, Henriksen Sj, C. Chavkin, D. Gruol (1986)
Opioid peptides and epileptogenesis in the limbic system: cellular mechanisms.Advances in neurology, 44
Y. Kanemitsu, M. Hosoi, P. Zhu, F. Weight, R. Peoples, Joseph McLaughlin, Li Zhang (2003)
Dynorphin A inhibits NMDA receptors through a pH-dependent mechanismMolecular and Cellular Neuroscience, 24
T. Seyfried, G. Glaser (1985)
A Review of Mouse Mutants as Genetic Models of EpilepsyEpilepsia, 26
E. Stögmann, A. Zimprich, C. Baumgartner, S. Aull‐Watschinger, V. Höllt, F. Zimprich (2002)
A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsyAnnals of Neurology, 51
Peng Xia, G. Pei, W. Schwarz (2006)
Regulation of the glutamate transporter EAAC1 by expression and activation of delta-opioid receptor.The European journal of neuroscience, 24 1
S. Khavandgar, H. Homayoun, A. Dehpour (2002)
The role of nitric oxide in the proconvulsant effect of δ-opioid agonist SNC80 in miceNeuroscience Letters, 329
A. Mazarati, Hantao Liu, C. Wasterlain (1999)
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticusNeuroscience, 89
C. Drake, T. Milner (1999)
Mu opioid receptors are in somatodendritic and axonal compartments of GABAergic neurons in rat hippocampal formationBrain Research, 849
S. Madamba, P. Schweitzer, G. Siggins (1999)
Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism.Journal of neurophysiology, 82 4
S. Clarke, A. Zimmer, A. Zimmer, R. Hill, I. Kitchen (2003)
Region selective up-regulation of μ-, δ- and κ-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout miceNeuroscience, 122
S. Comer, E. Hoenicke, A. Sable, R. Mcnutt, K. Chang, B. Costa, H. Mosberg, J. Woods (1993)
Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.The Journal of pharmacology and experimental therapeutics, 267 2
K. Svoboda, C. Lupica (1998)
Opioid Inhibition of Hippocampal Interneurons via Modulation of Potassium and Hyperpolarization-Activated Cation (Ih) CurrentsThe Journal of Neuroscience, 18
Neuropsychiatric disorders are one of the main challenges of human medicine with epilepsy being one of the most common serious disorders of the brain. Increasing evidence suggest neuropeptides, particularly the opioids, play an important role in epilepsy. However, little is known about the mechanisms of the endogenous opioid system in epileptogenesis and epilepsy. Therefore, we investigated the role of endogenous prodynorphin-derived peptides in epileptogenesis, acute seizure behaviour and epilepsy in prodynorphin-deficient mice.Compared with wild-type littermates, prodynorphin knockout mice displayed a significantly reduced seizure threshold as assessed by tail-vein infusion of the GABAA antagonist pentylenetetrazole. This phenotype could be entirely rescued by the kappa receptor-specific agonist U-50488, but not by the mu receptor-specific agonist DAMGO. The delta-specific agonist SNC80 decreased seizure threshold in both genotypes, wild-type and knockout. Pre-treatment with the kappa selective antagonist GNTI completely blocked the rescue effect of U-50488.Consistent with the reduced seizure threshold, prodynorphin knockout mice showed faster seizure onset and a prolonged time of seizure activity after intracisternal injection of kainic acid. Three weeks after local injection of kainic acid into the stratum radiatum CA1 of the dorsal hippocampus, prodynorphin knockout mice displayed an increased extent of granule cell layer dispersion and neuronal loss along the rostrocaudal axis of the ipsi- and partially also of the contralateral hippocampus. In the classical pentylenetetrazole kindling model, dynorphin-deficient mice showed significantly faster kindling progression with six out of eight animals displaying clonic seizures, while none of the nine wild-types exceeded rating 3 (forelimb clonus). Taken together, our data strongly support a critical role for dynorphin in the regulation of hippocampal excitability, indicating an anticonvulsant role of kappa opioid receptors, thereby providing a potential target for antiepileptic drugs.
Brain – Oxford University Press
Published: Apr 8, 2007
Keywords: temporal lobe epilepsy opioid system hippocampus seizure threshold excitatory neurotransmission
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.