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Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction

Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute... AimsWe studied plasma erythropoietin (EPO) levels and their relation with CD34VEGFR-2 (mature and progenitor endothelial cells) and CD34 CD133VEGFR-2, or CD34 CD117VEGFR-2 (early/immature endothelial progenitors) cells in patients with acute myocardial infarction (AMI).Methods and resultsFifty AMI patients undergoing percutaneous coronary intervention (PCI) within 6 h of symptom onset were enrolled. EPO, measured by ELISA, and cell subsets, by cytofluorimetric analysis, were evaluated before PCI, 24 h and 7 days afterwards. Forty-five healthy subjects (CTRLs) were studied. Plasma EPO levels were higher in AMI patients at admission, 24 h, and 7 days (P 0.04, P 0.0001, P 0.001, respectively) than in CTRLs. No correlation was evidenced between EPO and haemoglobin (Hb) or haematocrit at admission or 24 h after AMI. Differently, both Hb and haematocrit inversely correlated with EPO at day 7 (P 0.0016, P 0.029, respectively). Plasma EPO levels correlated with CD34CD133VEGFR-2 cells at day 7 (P 0.03).ConclusionAMI patients have increased plasma EPO levels until day 7. In the early phase, plasma EPO levels are Hb-independent; at day 7, an Hb-modulated increase of EPO correlates with the percentage of CD34CD133VEGFR-2 cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Heart Journal Oxford University Press

Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction

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References (40)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0195-668X
eISSN
1522-9645
DOI
10.1093/eurheartj/ehm065
pmid
17412728
Publisher site
See Article on Publisher Site

Abstract

AimsWe studied plasma erythropoietin (EPO) levels and their relation with CD34VEGFR-2 (mature and progenitor endothelial cells) and CD34 CD133VEGFR-2, or CD34 CD117VEGFR-2 (early/immature endothelial progenitors) cells in patients with acute myocardial infarction (AMI).Methods and resultsFifty AMI patients undergoing percutaneous coronary intervention (PCI) within 6 h of symptom onset were enrolled. EPO, measured by ELISA, and cell subsets, by cytofluorimetric analysis, were evaluated before PCI, 24 h and 7 days afterwards. Forty-five healthy subjects (CTRLs) were studied. Plasma EPO levels were higher in AMI patients at admission, 24 h, and 7 days (P 0.04, P 0.0001, P 0.001, respectively) than in CTRLs. No correlation was evidenced between EPO and haemoglobin (Hb) or haematocrit at admission or 24 h after AMI. Differently, both Hb and haematocrit inversely correlated with EPO at day 7 (P 0.0016, P 0.029, respectively). Plasma EPO levels correlated with CD34CD133VEGFR-2 cells at day 7 (P 0.03).ConclusionAMI patients have increased plasma EPO levels until day 7. In the early phase, plasma EPO levels are Hb-independent; at day 7, an Hb-modulated increase of EPO correlates with the percentage of CD34CD133VEGFR-2 cells.

Journal

European Heart Journal – Oxford University Press

Published: Aug 5, 2007

Keywords: Acute myocardial infarction Erythropoietin Vascular endothelial growth factor Endothelial progenitors

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