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- Publisher
- Oxford University Press
- Copyright
- © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
- ISSN
- 1462-0324
- eISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/ken014
- pmid
- 18316337
- Publisher site
- See Article on Publisher Site
Abstract
Post-translational modifications play a central role in determining the function of proteins. Such protein modifications come in a great variety of guises, and include phosphorylation, proteolysis, glycosylation, citrullination and oxidative modifications. In relation to inflammatory autoimmune diseases, some post-translational modifications appear to result in the generation of new antigens, and hence autoantibodies. Examples include: the induction of peptide immunogenicity by the spontaneous conversion of aspartic acid residues to isoaspartic acid; granzyme B-mediated cleavage of SLE autoantigens; the oxidative modification—on the surface of apoptotic cells—of lipids and proteins, rendering them immunogenic; and the presence of antibodies to oxidatively modified type II collagen and C1q in RA and SLE patients, respectively. The measurement of autoantibodies to citrullinated proteins has been verified as a very useful diagnostic tool in RA. Proteomics techniques, in principle, allow the detection of all types of in vivo protein modifications, and the increasing application of such technologies to the study of rheumatological diseases will further our understanding of autoantigenicity.
Journal
Rheumatology – Oxford University Press
Published: May 3, 2008
Keywords: Post-translational modification Protein oxidation Citrullination Oxidized low-density lipoprotein Inflammation Rheumatic diseases Anti-phospholipid syndrome Neo-antigenicity Autoantibody Apoptosis