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Comparative in vitro activities of the new quinolone nemonoxacin (TG-873870), gemifloxacin and other quinolones against clinical isolates of Mycobacterium tuberculosis

Comparative in vitro activities of the new quinolone nemonoxacin (TG-873870), gemifloxacin and... Journal of Antimicrobial Chemotherapy (2009) 64, 428–435 doi:10.1093/jac/dkp174 Advance Access publication 19 May 2009 In total, 109 non-duplicate and consecutive TB isolates, Comparative in vitro activities of the new recovered from various clinical specimens, were collected from quinolone nemonoxacin (TG-873870), gemifloxacin 2000 to 2007 at the National Taiwan University Hospital and other quinolones against clinical isolates of (NTUH). Susceptibility to first-line anti-TB drugs, including iso- Mycobacterium tuberculosis niazid (0.2 and 1.0 mg/L), rifampicin (1 mg/L) and ethambutol 1 2 3 (5 mg/L), and second-line anti-TB drugs, including streptomycin Che-Kim Tan , Chih-Cheng Lai , Chun-Hsing Liao , 4 5 5,6 (2 and 10 mg/L), rifabutin (0.5 mg/L), ofloxacin (2 mg/L), Chien-Hong Chou , Hsiao-Leng Hsu , Yu-Tsung Huang 5,6 ethionamide (5 mg/L) and para-aminosalicylic acid (2 mg/L), and Po-Ren Hsueh * was determined in the Mycobacteriology Laboratory of NTUH using modified, proportional, disc elution methods. A Department of Intensive Care Medicine, Chi-Mei Medical M. tuberculosis suspension was inoculated onto Middlebrook Center, Tainan, Taiwan; Department of Internal Medicine, 7H10 agar (BBL Microbiology Systems, Cockeysville, MD, USA) Yi-Min Hospital, Taipei, Taiwan; Department of Internal that contained anti-TB drugs at respective concentrations. The Medicine, Far Eastern Memorial Hospital, Taipei County, tested isolate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Antimicrobial Chemotherapy Oxford University Press

Comparative in vitro activities of the new quinolone nemonoxacin (TG-873870), gemifloxacin and other quinolones against clinical isolates of Mycobacterium tuberculosis

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References (10)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
Research letters
ISSN
0305-7453
eISSN
1460-2091
DOI
10.1093/jac/dkp174
pmid
19454523
Publisher site
See Article on Publisher Site

Abstract

Journal of Antimicrobial Chemotherapy (2009) 64, 428–435 doi:10.1093/jac/dkp174 Advance Access publication 19 May 2009 In total, 109 non-duplicate and consecutive TB isolates, Comparative in vitro activities of the new recovered from various clinical specimens, were collected from quinolone nemonoxacin (TG-873870), gemifloxacin 2000 to 2007 at the National Taiwan University Hospital and other quinolones against clinical isolates of (NTUH). Susceptibility to first-line anti-TB drugs, including iso- Mycobacterium tuberculosis niazid (0.2 and 1.0 mg/L), rifampicin (1 mg/L) and ethambutol 1 2 3 (5 mg/L), and second-line anti-TB drugs, including streptomycin Che-Kim Tan , Chih-Cheng Lai , Chun-Hsing Liao , 4 5 5,6 (2 and 10 mg/L), rifabutin (0.5 mg/L), ofloxacin (2 mg/L), Chien-Hong Chou , Hsiao-Leng Hsu , Yu-Tsung Huang 5,6 ethionamide (5 mg/L) and para-aminosalicylic acid (2 mg/L), and Po-Ren Hsueh * was determined in the Mycobacteriology Laboratory of NTUH using modified, proportional, disc elution methods. A Department of Intensive Care Medicine, Chi-Mei Medical M. tuberculosis suspension was inoculated onto Middlebrook Center, Tainan, Taiwan; Department of Internal Medicine, 7H10 agar (BBL Microbiology Systems, Cockeysville, MD, USA) Yi-Min Hospital, Taipei, Taiwan; Department of Internal that contained anti-TB drugs at respective concentrations. The Medicine, Far Eastern Memorial Hospital, Taipei County, tested isolate

Journal

Journal of Antimicrobial ChemotherapyOxford University Press

Published: Aug 19, 2009

Keywords: M. tuberculosis TB MDR-TB

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