Access the full text.
Sign up today, get DeepDyve free for 14 days.
I. Corraliza, M. Campo, G. Soler, M. Modolell (1994)
Determination of arginase activity in macrophages: a micromethod.Journal of immunological methods, 174 1-2
I. Wakabayashi (2007)
Age-dependent association of alcohol drinking with pulse pressureJournal of Hypertension, 25
(2008)
J Hypertens
Fabiana Bernardi, Larissa Constantino, R. Machado, F. Petronilho, F. Dal-Pizzol (2008)
Plasma nitric oxide, endothelin‐1, arginase and superoxide dismutase in pre‐eclamptic womenJournal of Obstetrics and Gynaecology Research, 34
J. Dumont, M. Zureik, D. Cottel, M. Montaye, P. Ducimetiere, P. Amouyel, T. Brousseau (2007)
Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima–media thicknessJournal of Medical Genetics, 44
Céline Bouvet, L. Gilbert, D. Girardot, D. Deblois, P. Moreau (2005)
Different Involvement of Extracellular Matrix Components in Small and Large Arteries During Chronic NO Synthase InhibitionHypertension, 45
H. Yokoyama, D. Averill, K. Brosnihan, Ronald Smith, E. Schiffrin, C. Ferrario (2005)
Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy.American journal of hypertension, 18 7
D. Berkowitz, R. White, Dechun Li, Khalid Minhas, Amy Cernetich, Soonyul Kim, S. Burke, A. Shoukas, D. Nyhan, H. Champion, J. Hare (2003)
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood VesselsCirculation: Journal of the American Heart Association, 108
L. Ignarro, G. Buga, L. Wei, P. Bauer, Guoyao Wu, P. Soldato (2001)
Inaugural Article: Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferationProceedings of the National Academy of Sciences of the United States of America, 98
Hui Li, C. Meininger, J. Hawker, T. Haynes, D. Kepka‐Lenhart, S. Mistry, S. Morris, Guoyao Wu (2001)
Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells.American journal of physiology. Endocrinology and metabolism, 280 1
F. Johnson, R. Johnson, K. Peyton, W. Durante (2005)
Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension.American journal of physiology. Regulatory, integrative and comparative physiology, 288 4
D. Endemann, R. Touyz, Jin-S. Li, L. Deng, E. Schiffrin (1999)
Altered angiotensin II-induced small artery contraction during the development of hypertension in spontaneously hypertensive rats.American journal of hypertension, 12 7
S. Ryoo, Gaurav Gupta, A. Benjo, H. Lim, A. Camara, G. Sikka, Hyun-Kyung Lim, Jayson Sohi, L. Santhanam, K. Soucy, Eric Tuday, E. Baraban, M. Ilieș, G. Gerstenblith, D. Nyhan, A. Shoukas, D. Christianson, N. Alp, H. Champion, D. Huso, D. Berkowitz (2008)
Endothelial Arginase II: A Novel Target for the Treatment of AtherosclerosisCirculation Research, 102
Cuihua Zhang, T. Hein, Wei Wang, Chiung-I Chang, L. Kuo (2001)
Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide‐mediated vasodilatory functionThe FASEB Journal, 15
C. Demougeot, A. Prigent-Tessier, T. Bagnost, C. André, Y. Guillaume, M. Bouhaddi, C. Marie, A. Berthelot (2007)
Time course of vascular arginase expression and activity in spontaneously hypertensive rats.Life sciences, 80 12
Lüscher Tf (1994)
The endothelium in hypertension: bystander, target or mediator?Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 12 10
G. Marano, M. Grigioni, S. Palazzesi, A. Ferrari (1999)
Endothelin and mechanical properties of the carotid artery in Wistar-Kyoto and spontaneously hypertensive rats.Cardiovascular research, 41 3
L. Pedelty, P. Gorelick (2004)
Chronic Management of Blood Pressure After StrokeHypertension: Journal of the American Heart Association, 44
C. Jenkinson, W. Grody, S. Cederbaum (1996)
Comparative properties of arginases.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 114 1
Arginase inhibition in hypertension
Lacy Holowatz, W. Kenney (2007)
Up‐regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humansThe Journal of Physiology, 581
T. Bagnost, A. Berthelot, M. Bouhaddi, P. Laurant, C. André, Y. Guillaume, C. Demougeot (2008)
Treatment with the arginase inhibitor Nω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive ratJournal of Hypertension, 26
W. Durante, F. Johnson, R. Johnson (2007)
ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTIONClinical and Experimental Pharmacology and Physiology, 34
Rosario Bravo, B. Somoza, M. Ruiz‐Gayo, C. González, L. Ruilope, M. Fernández-Alfonso (2001)
Differential Effect of Chronic Antihypertensive Treatment on Vascular Smooth Muscle Cell Phenotype in Spontaneously Hypertensive RatsHypertension: Journal of the American Heart Association, 37
T. Lüscher, Y. Dohi, M. Tschudi (1992)
Endothelium‐Dependent Regulation of Resistance Arteries: Alterations with Aging and HypertensionJournal of Cardiovascular Pharmacology, 19
G. Buga, Rajan Singh, S. Pervin, N. Rogers, Debra Schmitz, Christopher Jenkinson, Stephen Cederbaum, L. Ignarro (1996)
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production.The American journal of physiology, 271 5 Pt 2
D. Meroufel, J. Dumont, S. Médiène-Benchekor, Soraya Benhammamouch, P. Ducimetiere, D. Cottel, M. Montaye, P. Amouyel, T. Brousseau (2009)
Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure.Clinical biochemistry, 42 10-11
K. Peyton, Diana Ensenat, M. Azam, A. Keswani, S. Kannan, Xiao-ming Liu, Hong Wang, D. Tulis, W. Durante (2009)
Arginase Promotes Neointima Formation in Rat Injured Carotid ArteriesArteriosclerosis, Thrombosis, and Vascular Biology, 29
V. Mollace, C. Muscoli, E. Masini, S. Cuzzocrea, D. Salvemini (2005)
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide DonorsPharmacological Reviews, 57
P. Fridez, A. Makino, H. Miyazaki, Jean-Jacques Meister, Kozaburo Hayashi, N. Stergiopulos (2004)
Short-Term Biomechanical Adaptation of the Rat Carotid to Acute Hypertension: Contribution of Smooth MuscleAnnals of Biomedical Engineering, 29
Michel Safar, P. Chamiot-Clerc, Georges Dagher, J. Renaud (2001)
Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats.Hypertension, 38 6
Cuihua Zhang, T. Hein, Wei Wang, Matthew Miller, T. Fossum, M. McDonald, J. Humphrey, L. Kuo (2004)
Upregulation of Vascular Arginase in Hypertension Decreases Nitric Oxide–Mediated Dilation of Coronary ArteriolesHypertension, 44
H. Masuda (2008)
Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunctionInternational Journal of Urology, 15
S. Wallace, Yasmin, C. McEniery, K. Mäki-Petäjä, A. Booth, J. Cockcroft, I. Wilkinson (2007)
Isolated Systolic Hypertension Is Characterized by Increased Aortic Stiffness and Endothelial DysfunctionHypertension, 50
C. Demougeot, A. Prigent-Tessier, C. Marie, A. Berthelot (2005)
Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive ratsJournal of Hypertension, 23
S. Rodriguez, L. Richert, A. Berthelot (2000)
INCREASED ARGINASE ACTIVITY IN AORTA OF MINERALOCORTICOID-SALT HYPERTENSIVE RATSClinical and Experimental Hypertension, 22
M. Montagnani, M. Potenza, R. Rinaldi, G. Mansi, C. Nacci, M. Serio, V. Vulpis, A. Pirrelli, D. Mitolo‐chieppa (1999)
Functional characterization of endothelin receptors in hypertensive resistance vessels.Journal of hypertension, 17 1
Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular
E. Fonck, Gilles Prod'hom, Sylvain Roy, L. Augsburger, D. Rüfenacht, N. Stergiopulos (2007)
Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model.American journal of physiology. Heart and circulatory physiology, 292 6
(2008)
Insulin reduces plasma arginase activity in type 2 diabetic patients
Hanzhong Liu, J. Ledingham, I. Mullaney, R. Laverty (2002)
Endothelial Function In Mesenteric Resistance Arteries From The Genetically Hypertensive RatClinical and Experimental Pharmacology and Physiology, 29
R. Aras-Lopéz, J. Blanco-Rivero, F. Xavier, M. Salaices, M. Ferrer, G. Balfagón (2007)
Dexamethasone Decreases Contraction to Electrical Field Stimulation in Mesenteric Arteries from Spontaneously Hypertensive Rats through Decreases in Thromboxane A2 ReleaseJournal of Pharmacology and Experimental Therapeutics, 322
H. Girouard, J. Champlain (2005)
Acute and chronic effects of free radicals on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats.Journal of hypertension, 23 4
D. Lipke, P. Newman, S. Tofiq, H. Guo, S. Arcot, S. Aziz, J. Olson, E. Soltis (1997)
Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension.Clinical and experimental hypertension, 19 3
H. Girouard, J. Champlain (2005)
Acute and chronic effects of free radicals on α1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive ratsJournal of Hypertension, 23
Y. Álvarez, J. Pérez-Girón, R. Hernanz, A. Briones, A. García-Redondo, A. Beltrán, M. Alonso, M. Salaices (2007)
Losartan Reduces the Increased Participation of Cyclooxygenase-2-Derived Products in Vascular Responses of Hypertensive RatsJournal of Pharmacology and Experimental Therapeutics, 321
H. Intengan, E. Schiffrin (2001)
Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and FibrosisHypertension: Journal of the American Heart Association, 38
Jamila Ibrahim, Alun Hughes, M. Schachter, P. Sever (1996)
ENHANCED TISSUE POLYAMINE CONTENT IN THE SPONTANEOUSLY HYPERTENSIVE RATClinical and Experimental Pharmacology and Physiology, 23
Xinkang Wang, J. Keith, A. Struthers, G. Feuerstein (2008)
Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk.Cardiovascular therapeutics, 26 3
J. Redón (2005)
Antihypertensive treatment: should it be titrated to blood pressure reduction or to target organ damage regression?Current Opinion in Nephrology and Hypertension, 14
AimsGrowing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we investigated the potential cardiovascular therapeutic effects of a long-term treatment with an arginase inhibitor in adult spontaneously hypertensive rats (SHR) with fully developed hypertension.Methods and resultsTreatment of 25-week-old SHR with the arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA, 40 mg/day for 10 weeks) sustainably reduced systolic blood pressure (30 mmHg, P < 0.05). The antihypertensive effect of nor-NOHA was associated with changes on mesenteric artery reactivity including the restoration of angiotensin-II-induced contraction and acetylcholine-induced vasodilation to the values of normotensive Wistar Kyoto rats. Both nitric oxide synthase and cyclooxygenase-dependent mechanisms account for the improvement of endothelial function afforded by the arginase inhibitor, which in addition blunted hypertension-induced endothelial arginase I overexpression in mesenteric arteries. Nor-NOHA also prevented the remodelling of aorta as measured by collagen content and media/lumen ratio, and improved the compliance of carotid artery in SHR. Cardiac fibrosis assessed by collagen content of left heart ventricle was reduced by nor-NOHA, with no significant effect on cardiac hypertrophy.ConclusionOur results report that a long-term treatment with an arginase inhibitor reduced blood pressure, improved vascular function, and reduced cardiac fibrosis in SHR with fully developed hypertension. These data suggest that arginase represents a promising novel target for pharmacological intervention in essential hypertension.
Cardiovascular Research – Oxford University Press
Published: Aug 1, 2010
Keywords: Arginase Arteries Endothelial function Remodelling Spontaneously hypertensive rat
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.