The term 'cell fusion' acquired a pejorative connotation in the field of cell transplantation when it was discovered to underly the misinterpretation that cells of one lineage could transdifferentiate into cells of developmentally unrelated lineages. However, the process itself actually has an important biological role in the development, physiology and disease of multicellular organisms. Examples include zygote formation and organogenesis of various tissues, such as placenta, bone and skeletal muscle. Homotypic fusion between myoblasts is the basis for the formation and growth of multinuclear myofibres. Moreover, the emergence of multinucleated cells during chronic inflammatory conditions is the result of cell fusion . Experimentally-induced cell fusion (for example, electrofusion, fusiogenic viruses) has been used since the 1970s to generate immortalized cell lines, to produce monoclonal antibodies and to study gene regulation. The importance of cell fusion as a tool for studying epigenetic reprogramming, cell fate manipulation and pluripotency is currently experiencing a renaissance . Two papers in this issue, one by Johansson et al . and the other by Nygren et al . , address heterotypic cell fusion in various in vivo models to characterize more fully the conditions that trigger fusion between blood and solid-organ cells. Heterotypic cell
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Inflammation as a matchmaker: revisiting cell fusion
Singec, Ilyas; Snyder, Evan Y.
Follow Nature Cell Biology
, Volume 10 (5)
Nature Publishing Group (NPG) – May 1, 2008
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