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biosynthetic pathway can transform, both in vitro and in cells, a synthetic carbohydrate precursor into the nucleotide sugar analogue. Treatment of cells with the precursor decreases O-GlcNAc in a targeted ...
, potentially altering protein characteristics. Finally, sugar biosynthetic pathways in the prokaryotic host may need to be altered to drive sugar precursors towards the required product. To resolve ...
seedlings. A number of genes encoding pathogen-responsive uridine-diphosphate glycosyltransferases (UGTs) potentially involved in detoxification of the Fusarium mycotoxin deoxynivalenol (DON) were ...
distinguish OGT as a unique glycosyltransferase that is distinct from canonical eukaryotic glycosyltransferases , which act exclusively in the secretory pathway to assemble the oligosaccharides found on cell ...
Abstract The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways , typically mediated by post-translational protein modifications ...
that changes in secondary metabolites in leaves of AM plants correlate with the transcriptional regulation of related biosynthetic pathways . These modifications coincide with the specific modulation ...
; Matthysse et al. 2004). Even some giant viruses, such as members of the Pandoravirus genus, incorporate cellulose in their tegument, likely through hijacking their host's biosynthetic machinery during ...
WF , Heinonen JE , Shen DL , Deng L , Vocadlo DJ . 2011 . Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells . Nat Chem Biol . 7 : 174 – 181 . Google Scholar Crossref ...
in glycan biosynthetic pathways . These include variations in the expression of glycosyltransferases , enzymes that add activated donor monosaccharides in specific stereochemistries to acceptors, i.e., growing ...
where they hijack the host cell’s glycosylation machinery and get decorated with glycans [19]. Protein glycosylation is controlled by hundreds of glycosyltransferases that reside in the secretory pathway ...
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