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Journals Nature Chemical Biology Volume 6 Issue 7

Sphingolipids comprise a complex family of naturally occurring molecules that are enriched in lipid rafts and contribute to their unique biochemical properties. Membrane sphingolipids also serve as a reservoir for bioactive metabolites including sphingosine, ceramide, sphingosine-1-phosphate and ceramide-1-phosphate. Among these, sphingosine-1-phosphate has emerged as a central regulator of mammalian biology. Sphingosine-1-phosphate is essential for mammalian brain and cardiac development and for maturation of the systemic circulatory system and lymphatics. In addition, sphingosine-1-phosphate contributes to trafficking and effector functions of lymphocytes and other hematopoietic cells and protects against various forms of tissue injury. However, sphingosine-1-phosphate is also an oncogenic lipid that promotes tumor growth and progression. Recent preclinical and clinical investigations using pharmacological agents that target sphingosine-1-phosphate, its receptors and the enzymes required for its biosynthesis and degradation demonstrate the promise and potential risks of modulating sphingosine-1-phosphate signaling in treatment strategies for autoimmunity, cancer, cardiovascular disease and other pathological conditions.

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An update on sphingosine-1-phosphate and other sphingolipid mediators

Fyrst, Henrik; Saba, Julie D
Nature Chemical Biology , Volume 6 (7)
Nature Publishing Group (NPG) – Jul 1, 2010

More Info
  • Publisher Nature Publishing Group
  • Copyright Copyright © 2010 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
  • ISSN 1552-4450
  • eISSN 1552-4469
  • D.O.I. 10.1038/nchembio.392
  • Publisher site Get PDF  

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