Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Wilke (2001)
Adaptive evolution on neutral networksBulletin of Mathematical Biology, 63
D. Goldberg, B. Korb, K. Deb (1989)
Messy Genetic Algorithms: Motivation, Analysis, and First ResultsComplex Syst., 3
A. Barabási, Z. Oltvai (2004)
Network biology: understanding the cell's functional organizationNature Reviews Genetics, 5
G. Wagner, L. Altenberg (1996)
PERSPECTIVE: COMPLEX ADAPTATIONS AND THE EVOLUTION OF EVOLVABILITYEvolution, 50
J. Pepper (2003)
The evolution of evolvability in genetic linkage patterns.Bio Systems, 69 2-3
B. Sinervo, E. Svensson (2002)
Correlational selection and the evolution of genomic architectureHeredity, 89
S. Wuchty (2004)
Evolution and topology in the yeast protein interaction network.Genome research, 14 7
C. Knibbe, G. Beslon, V. Lefort, F. Chaudier, J. Fayard (2005)
Self-adaptation of Genome Size in Artificial Organisms
Warren Lathe, B. Snel, Peer Bork (2000)
Gene context conservation of a higher order than operons.Trends in biochemical sciences, 25 10
C. Wilke, Jia Wang, C. Ofria, R. Lenski, C. Adami (2001)
Evolution of digital organisms at high mutation rates leads to survival of the flattestNature, 412
C. Knibbe, O. Mazet, F. Chaudier, J. Fayard, G. Beslon (2007)
Evolutionary coupling between the deleteriousness of gene mutations and the amount of non-coding sequences.Journal of theoretical biology, 244 4
L. Zadeh (1999)
Fuzzy sets as a basis for a theory of possibilityFuzzy Sets and Systems, 100
Hawoong Jeong, S. Mason, A. Barabási, Z. Oltvai (2001)
Lethality and centrality in protein networksNature, 411
Hawoong Jeong, B. Tombor, Réka Albert, Z. Oltvai, A. Barabási (2000)
The large-scale organization of metabolic networksNature, 407
H. Kitano (2002)
Systems Biology: A Brief OverviewScience, 295
L. Valiant (2009)
EvolvabilityElectron. Colloquium Comput. Complex., TR06
Günter Wagner, L. Altenberg (2005)
Complex Adaptations and the Evolution of Evolvability
T. Blickle, L. Thiele (1996)
A Comparison of Selection Schemes Used in Evolutionary AlgorithmsEvolutionary Computation, 4
L. Hurst, Csaba Pál, M. Lercher (2004)
The evolutionary dynamics of eukaryotic gene orderNature Reviews Genetics, 5
E. Nimwegen, J. Crutchfield, M. Huynen (1999)
Neutral evolution of mutational robustness.Proceedings of the National Academy of Sciences of the United States of America, 96 17
D. Misevic, C. Ofria, R. Lenski (2006)
Sexual reproduction reshapes the genetic architecture of digital organismsProceedings of the Royal Society B: Biological Sciences, 273
Andreas Wagner, D. Fell (2000)
The small world inside large metabolic networksProceedings of the Royal Society of London. Series B: Biological Sciences, 268
J. Lawrence (1999)
Selfish operons: the evolutionary impact of gene clustering in prokaryotes and eukaryotes.Current opinion in genetics & development, 9 6
G. Beslon, David Parsons, Yolanda Sanchez-Dehesa, J. Peña, C. Knibbe (2010)
Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness?Bio Systems, 102 1
M. Babu, N. Luscombe, L. Aravind, M. Gerstein, Sarah Teichmann (2004)
Structure and evolution of transcriptional regulatory networks.Current opinion in structural biology, 14 3
S. Shimeld (1999)
Gene function, gene networks and the fate of duplicated genes.Seminars in cell & developmental biology, 10 5
Charles Darwin (1930)
The Genetical Theory of Natural SelectionNature, 126
P. Crucitti, V. Latora, Massimo Marchiori, Andrea Rapisarda (2004)
Error and attacktolerance of complex network s
D. Burke, K. Jong, J. Grefenstette, C. Ramsey, A. Wu (1998)
Putting More Genetics into Genetic AlgorithmsEvolutionary Computation, 6
N. Chandra (2009)
Computational systems approach for drug target discoveryExpert Opinion on Drug Discovery, 4
R. Albert, Hawoong Jeong, A. Barabási (2000)
Error and attack tolerance of complex networksNature, 406
Systems biology invites us to consider the dynamic interactions between the components of a living cell. Here, by evolving artificial organisms whose genomes encode protein networks, we show that a coupling emerges at the evolutionary time scale between the protein network and the structure of the genome. Gene order is more stable when the protein network is more densely connected, which most likely results from a long-term selection for mutational robustness. Understanding evolving organisms thus requires a systemic approach, taking into account the functional interactions between gene products, but also the global relationships between the genome and the proteome at the evolutionary time scale.
Artificial Life – MIT Press
Published: Jan 1, 2008
Keywords: Genome dynamics; gene order; protein network; evolvability; robustness
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.