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The Topology of the Protein Network Influences the Dynamics of Gene Order: From Systems Biology to a Systemic Understanding of Evolution

The Topology of the Protein Network Influences the Dynamics of Gene Order: From Systems Biology... Systems biology invites us to consider the dynamic interactions between the components of a living cell. Here, by evolving artificial organisms whose genomes encode protein networks, we show that a coupling emerges at the evolutionary time scale between the protein network and the structure of the genome. Gene order is more stable when the protein network is more densely connected, which most likely results from a long-term selection for mutational robustness. Understanding evolving organisms thus requires a systemic approach, taking into account the functional interactions between gene products, but also the global relationships between the genome and the proteome at the evolutionary time scale. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Artificial Life MIT Press

The Topology of the Protein Network Influences the Dynamics of Gene Order: From Systems Biology to a Systemic Understanding of Evolution

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References (31)

Publisher
MIT Press
Copyright
© 2008 Massachusetts Institute of Technology
Subject
Articles
ISSN
1064-5462
eISSN
1530-9185
DOI
10.1162/artl.2008.14.1.149
pmid
18171137
Publisher site
See Article on Publisher Site

Abstract

Systems biology invites us to consider the dynamic interactions between the components of a living cell. Here, by evolving artificial organisms whose genomes encode protein networks, we show that a coupling emerges at the evolutionary time scale between the protein network and the structure of the genome. Gene order is more stable when the protein network is more densely connected, which most likely results from a long-term selection for mutational robustness. Understanding evolving organisms thus requires a systemic approach, taking into account the functional interactions between gene products, but also the global relationships between the genome and the proteome at the evolutionary time scale.

Journal

Artificial LifeMIT Press

Published: Jan 1, 2008

Keywords: Genome dynamics; gene order; protein network; evolvability; robustness

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