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J. Micallef-Roll, P. Rihet, T. Hasbroucq, C. Possamaï, O. Blin (2001)
Levodopa-induced Drowsiness in Healthy Volunteers: Results of a Choice Reaction Time Test Combined with a Subjective Evaluation of SedationClinical Neuropharmacology, 24
D. Liberman (1955)
[Time perception].Revista de psicoanalisis, 12 3
C. Malapani, B. Deweer, J. Gibbon (2002)
Separating Storage from Retrieval Dysfunction of Temporal Memory in Parkinson's DiseaseJournal of Cognitive Neuroscience, 14
M. Matell, W. Meck (2000)
Neuropsychological mechanisms of interval timing behavior.BioEssays : news and reviews in molecular, cellular and developmental biology, 22 1
Y. Misu, Y. Goshima, H. Ueda, H. Okamura (1996)
NEUROBIOLOGY OF l-DOPAergic SYSTEMSProgress in Neurobiology, 49
L. Allan, J. Gibbon (1991)
Human bisection at the geometric meanLearning and Motivation, 22
PA Lewis, RC Miall (2003)
Distinct systems for automatic and cognitively controlled time measurement: evidence from neuroimagingCurrent Opinion in Neurobiology, 13
M. Richards, K. Marder, K. Bell, G. Dooneief, R. Mayeux, Y. Stern (1991)
Interrater reliability of extrapyramidal signs in a group assessed for dementia.Archives of neurology, 48 11
V. Kaasinen, J. Rinne (2002)
Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's diseaseNeuroscience & Biobehavioral Reviews, 26
J. Haycock, L. Becker, L. Ang, Y. Furukawa, O. Hornykiewicz, S. Kish (2003)
Marked disparity between age‐related changes in dopamine and other presynaptic dopaminergic markers in human striatumJournal of Neurochemistry, 87
O. Hornykiewicz (1989)
Ageing and neurotoxins as causative factors in idiopathic parkinson's disease—a critical analysis of the neurochemical evidenceProgress in Neuro-Psychopharmacology and Biological Psychiatry, 13
Y. Stern, M. Sano, Janet Paulson, R. Mayeux (1987)
Modified Mini-Mental State Examination: Validity and ReliabilityNeurology, 37
T. Rammsayer (1999)
Neuropharmacological Evidence for Different Timing Mechanisms in HumansQuarterly Journal of Experimental Psychology, 52
W. Meck (1983)
Selective adjustment of the speed of internal clock and memory processes.Journal of experimental psychology. Animal behavior processes, 9 2
V. Kaasinen, H. Vilkman, J. Hietala, K. Någren, H. Helenius, H. Olsson, L. Farde, J. Rinne (2000)
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brainNeurobiology of Aging, 21
L. Bäckman, N. Ginovart, R. Dixon, T. Wahlin, Å. Wahlin, C. Halldin, L. Farde (2000)
Age-related cognitive deficits mediated by changes in the striatal dopamine system.The American journal of psychiatry, 157 4
F. Craik, J. Hay (1999)
Aging and judgments of duration: Effects of task complexity and method of estimationPerception & Psychophysics, 61
N. Volkow, Gene-Jack Wang, J. Fowler, S. Gatley, J. Logan, Yu-Shin Ding, R. Hitzemann, N. Pappas (1998)
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.The American journal of psychiatry, 155 10
Thomas Rammsayer (1989)
Is there a common dopaminergic basis of time perception and reaction time?Neuropsychobiology, 21 1
Richard Block, D. Zakay, Peter Hancock (1998)
Human aging and duration judgments: a meta-analytic review.Psychology and aging, 13 4
A. Wing, A. Kristofferson (1973)
Response delays and the timing of discrete motor responsesPerception & Psychophysics, 14
(2002)
Neurobiology of timing
A. Santi, L. Weise, D. Kuiper (1995)
Amphetamine and memory for event duration in rats and pigeons: Disruption of attention to temporal samples rather than changes in the speed of the internal clockPsychobiology
A. Arnsten, J. Cai, JC Steere, P. Goldman‐Rakic (1995)
Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys, 15
S. Perbal, S. Droit-Volet, M. Isingrini, V. Pouthas (2002)
Relationships Between Age-Related Changes in Time Estimation and Age-Related Changes in Processing Speed, Attention, and MemoryAging, Neuropsychology, and Cognition, 9
W. Meck, R. Church (1983)
A mode control model of counting and timing processes.Journal of experimental psychology. Animal behavior processes, 9 3
J. Diedrichsen, R. Ivry, J. Pressing (2003)
Cerebellar and basal ganglia contributions to interval timing
Psychiatry Research
T. Hasbroucq, C. Tandonnet, J. Micallef-Roll, O. Blin, C. Possamaï (2002)
An electromyographic analysis of the effect of levodopa on the response time of healthy subjectsPsychopharmacology, 165
J. Wearden, Bairbre McShane (1988)
Interval production as an analogue of the peak procedure: Evidence for similarity of human and animal timing processesQuarterly Journal of Experimental Psychology, 40
L. Stanford, A. Santi (1998)
The dopamine D2 agonist quinpirole disrupts attention to temporal signals without selectively altering the speed of the internal clockPsychobiology
C. Lustig, W. Meck (2001)
Paying Attention to Time as one Gets OlderPsychological Science, 12
Thomas Rammsayer, Wolfgang Vogel (1992)
Pharmacologic properties of the internal clock underlying time perception in humans.Neuropsychobiology, 26 1-2
(1988)
Dementia Rating Scale (DRS). Odessa, FL: Psychological Assessment Resources
D. Frederick, Joseph Allen (1996)
Effects of selective dopamine D1- and D2-agonists and antagonists on timing performance in ratsPharmacology Biochemistry and Behavior, 53
H. Ollat (1992)
Dopaminergic insufficiency reflecting cerebral ageing: value of a dopaminergic agonist, piribedilJournal of Neurology, 239
Teresa McCormack, Gordon Brown, E. Maylor, R. Darby, D. Green (1999)
Developmental changes in time estimation: comparing childhood and old age.Developmental psychology, 35 4
Ewart Thomas, Wanda Weaver (1975)
Cognitive processing and time perceptionPerception & Psychophysics, 17
T. Suhara, O. Inoue, Kaoru Kobayashi, Kazutoshi Suzuki, Y. Tateno (1993)
Age-related changes in human muscarinic acetylcholine receptors measured by positron emission tomographyNeuroscience Letters, 149
W. Meck (2002)
Choline Uptake in the Frontal Cortex Is Proportional to the Absolute Error of a Temporal Memory Translation Constant in Mature and Aged RatsLearning and Motivation, 33
E. Shea-Brown, J. Rinzel, B. Rakitin, C. Malapani (2006)
A firing rate model of Parkinsonian deficits in interval timingBrain Research, 1070
J. Wearden, A. Wearden, P. Rabbitt (1997)
Age and IQ effects on stimulus and response timingJournal of Experimental Psychology: Human Perception and Performance, 23
Y. Agid, P. Cervera, E. Hirsch, F. Javoy‐Agid, S. Lehéricy, R. Raisman, M. Ruberg (1989)
Biochemistry of Parkinson's disease 28 years later: A critical reviewMovement Disorders, 4
C. Buhusi, W. Meck (2002)
Differential effects of methamphetamine and haloperidol on the control of an internal clock.Behavioral neuroscience, 116 2
A. Maricq, S. Roberts, R. Church (1981)
Methamphetamine and time estimation.Journal of experimental psychology. Animal behavior processes, 7 1
J. Gibbon, C. Malapani, C. Dale, C. Gallistel (1997)
Toward a neurobiology of temporal cognition: advances and challengesCurrent Opinion in Neurobiology, 7
J. Cohen, B. MacWhinney, M. Flatt, Jefferson Provost (1993)
PsyScope: An interactive graphic system for designing and controlling experiments in the psychology laboratory using Macintosh computersBehavior Research Methods, Instruments, & Computers, 25
Sandrine Vanneste, Viviane Pouthas (1999)
Timing in aging: the role of attention.Experimental aging research, 25 1
A. Maricq, R. Church (2004)
The differential effects of haloperidol and methamphetamine on time estimation in the ratPsychopharmacology, 79
Brian Scholla, Zenon Pylyshynb, Jacob Feldmanb (1997)
PII: S0010-0277(00)00157-8
L. Mead, S. Stevens (1951)
Handbook of experimental psychology
B. Rakitin, Y. Stern, C. Malapani (2005)
The effects of aging on time reproduction in delayed free-recallBrain and Cognition, 58
G. Schroth, J. Gawehn, A. Thron, A. Vallbracht, K. Voigt (1987)
Early diagnosis of herpes simplex encephalitis by MRINeurology, 37
J. Gibbon, R. Church, W. Meck (1984)
Scalar Timing in MemoryAnnals of the New York Academy of Sciences, 423
(1993)
Psyscope: A new graphic interactive environment for designing psychology experiments
N. Chater (1999)
The Search for Simplicity: A Fundamental Cognitive Principle?Quarterly Journal of Experimental Psychology, 52
C. Malapani, B. Rakitin, R. Lévy, W. Meck, B. Deweer, B. Dubois, J. Gibbon (1998)
Coupled Temporal Memories in Parkinson's Disease: A Dopamine-Related DysfunctionJournal of Cognitive Neuroscience, 10
D. O'Boyle, J. Freeman, F. Cody (1996)
The accuracy and precision of timing of self-paced, repetitive movements in subjects with Parkinson's disease.Brain : a journal of neurology, 119 ( Pt 1)
W. Meck (2003)
Functional and neural mechanisms of interval timing
N. Volkow, R. Gur, Gene-Jack Wang, J. Fowler, P. Moberg, Yu-Shin Ding, R. Hitzemann, Gwenn Smith, J. Logan (1998)
Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals.The American journal of psychiatry, 155 3
T. Braver, D. Barch (2002)
A theory of cognitive control, aging cognition, and neuromodulationNeuroscience & Biobehavioral Reviews, 26
Thomas Rammsayer (1994)
A cognitive-neuroscience approach for elucidation of mechanisms underlying temporal information processing.The International journal of neuroscience, 77 1-2
B. Rakitin, C. Malapani (2003)
Interval Timing in the Dopamine-Depleted Basal Ganglia: From Empirical Data to Timing Theory
R. Ivry, R. Hazeltine (1995)
Perception and production of temporal intervals across a range of durations: evidence for a common timing mechanism.Journal of experimental psychology. Human perception and performance, 21 1
W. Meck (1996)
Neuropharmacology of timing and time perception.Brain research. Cognitive brain research, 3 3-4
N. Volkow, Gene-Jack Wang, J. Fowler, J. Logan, S. Gatley, R. Macgregor, D. Schlyer, R. Hitzemann, A. Wolf (1996)
Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidolPsychiatry Research: Neuroimaging, 67
Maria Pastor, J. Artieda, Marjan Jahanshahi, J. Obeso (1992)
Time estimation and reproduction is abnormal in Parkinson's disease.Brain : a journal of neurology, 115 Pt 1
Maria Pastor, Marjan Jahanshahi, J. Artieda, J. Obeso (1992)
Performance of repetitive wrist movements in Parkinson's disease.Brain : a journal of neurology, 115 ( Pt 3)
Tetsuya Suhara, Hiroshi Fukuda, Osamu Inoue, T. Itoh, Kazutoshi Suzuki, T. Yamasaki, Yukio Tateno (2005)
Age-related changes in human D1 dopamine receptors measured by positron emission tomographyPsychopharmacology, 103
Thomas Rammsayer (1997)
Are there dissociable roles of the mesostriatal and mesolimbocortical dopamine systems on temporal information processing in humans?Neuropsychobiology, 35 1
B. Rakitin (2005)
The effects of spatial stimulus-response compatibility on choice time production accuracy and variability.Journal of experimental psychology. Human perception and performance, 31 4
W. Meck (1986)
Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clockPharmacology Biochemistry and Behavior, 25
Warren Meck, Russell Church (1987)
Cholinergic modulation of the content of temporal memory.Behavioral neuroscience, 101 4
(1988)
Dementia Rating Scale (DRS)
B. Rakitin, J. Gibbon, T. Penney, C. Malapani, S. Hinton, W. Meck (1998)
Scalar expectancy theory and peak-interval timing in humans.Journal of experimental psychology. Animal behavior processes, 24 1
W. Meck, Aimée Benson (2002)
Dissecting the Brain's Internal Clock: How Frontal–Striatal Circuitry Keeps Time and Shifts AttentionBrain and Cognition, 48
M. Treisman (1963)
Temporal discrimination and the indifference interval. Implications for a model of the "internal clock".Psychological monographs, 77 13
R. Newman, P. LeWitt, M. Jaffe, D. Calne, T. Larsen (1985)
Motor function in the normal aging population: treatment with levodopa.Neurology, 35 4
R. Ivry, R. Spencer (2004)
The neural representation of timeCurrent Opinion in Neurobiology, 14
We tested the hypothesis that age-related time production deficits are dopamine-mediated. The experiment was conducted double-blind, and with random assignment of 32 healthy aged and 32 healthy young participants to either inert placebo or levodopa (200 mg) groups. The procedure included training participants to produce two target time intervals (6 and 17 sec) in separate blocks, drug/placebo administration, a 1-hr delay, and then delayed free-recall time production retesting without feedback. Participants also performed a speeded choice reaction time (RT) task, as a control for potential dopaminergic and aging effects on attention and psychomotor speed. Results indicate that during retesting, aged participants show duration-dependent timing errors that are larger than those shown by the young participants. Levodopa administration yielded lengthened time production of both target intervals. The aging and levodopa effects did not interact. Also, aging slowed RT and increased RT variability, but levodopa had no effect on the RT. These results suggest that at this dosage and under these specific conditions, timing is dopamine-mediated but the effect of aging on time production is not. Moreover, the levodopa timing effect cannot be attributed to the effects of dopaminergic function on psychomotor speed.
Journal of Cognitive Neuroscience – MIT Press
Published: Mar 1, 2006
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