Disease Models, Animal
Definition: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Articles related to this term...
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Model Of Destructive Tuberculosis In Guinea Pigs
Biulleten' eksperimental'no? biologii i meditsiny
Two series of experiments were made to develop experimental cavernous tuberculosis of the lungs in guinea-pigs. For preliminary sensitization, the Freund adjuvant was used in the first series of experiments, whereas the BCG vaccine was employed in the second s...
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Modeling Of Determinant And Dependent Foci Of Epileptic Activity In The Rat Cerebral Cortex
Biulleten' eksperimental'no? biologii i meditsiny
Foci of increased excitability were created in acute experiments on rats by means of weak strychnine solutions working at independent regimens. The hyperactive excitability focus induced by means of concentrated strychnine solutions played the role of a determ...
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Frequency, Time And Type Of Metastasis Of Different Transplantable Tumors In Mice
Biulleten' eksperimental'no? biologii i meditsiny
The character of metastasis of 9 strains of transplantable mouse tumours in conventional subcutaneous inoculation was studied. There were differences in the frequency, intensity, and types of metastasis of different tumours. Periods of onset of metastases of L...
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Formation Of Colonies Of P-388 Leukemic Cells In Semisolid Agar
Biulleten' eksperimental'no? biologii i meditsiny
Substrain P-388/A2 adapted to cultivation of agar gel in the form of compact colonies was obtained as a result of alternating passages of cells of ascitic mouse leukemia P-388 in the primary semifluid agar culture and in the mouse abdominal cavity. The efficac...
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Model Of Disseminated Intravascular Coagulation
Biulleten' eksperimental'no? biologii i meditsiny
Vascular-thrombocytic and plasma hemostasis was studied in dogs after blood loss (40--50 ml/kg weight) and subsequent hypervolemic (60--65 ml/kg weight) transfusion of homologous (from 3 donors) platelet and leukocyte rich in plasma. After a short phase of hyp...
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Modeling Experimental Pollinosis
Biulleten' eksperimental'no? biologii i meditsiny
Experimental pollinosis was modelled on guinea pigs. The animals were placed in a cell in which an allergen-water-dialyzed extract of ambrosia pollen was dispersed by means of coaxial pulveriser. Homocytotropic antibodies serving as indices of animal sensitiza...
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Modeling Neuropathologic Syndromes By Creating Generators Of Pathologically Enhanced Excitation In The Hypothalamus Of Rabbits
Biulleten' eksperimental'no? biologii i meditsiny
In the experiments on free behavior rabbits, tetanus toxin was injected into "pacemaker" motivational emotiogenic regions of the hypothalamus to form generators of pathologically enhanced excitation; this produced stable, long-term disorders in motivational-em...
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Healing Of Experimental Wounds Under The Effect Of X-Ray Irradiation At High Altitude
Biulleten' eksperimental'no? biologii i meditsiny
Experiments were conducted on 969 mature rabbits; combined radiation injury (in general irradiation with 500 r and even more so in local irradiation with 2000 r) inflicated during the first two adaptation phases (particularly the first one) to the high altitid...
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Experimental Toxic Pulmonary Edema In White Mice With Influenza
Biulleten' eksperimental'no? biologii i meditsiny
Toxic pulmonary edema during influenza developed 3 hours after infection of mice with concentrated influenza viruses adapted to lung tissue. The toxic viral action is expressed in filling the alveoli with fluid exudate, by stasis in the pulmonary vessels, by e...
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Metastasis Of Sarcoma 45 And 536 Following Different Methods Of Inoculation
Biulleten' eksperimental'no? biologii i meditsiny
Intertesticular inoculation to rats of 1 ml of sarcoma suspension was accompanied by a rapid growth of the tumour at the site of inoculation and the spread of the tumour nodes to the omentum majus, porta hepatis, mesentery and the abdominal walls. After intrap...
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Model Of A Chronic Vibrio Cholerae Carrier Based On Gnotobiotic Rats
Biulleten' eksperimental'no? biologii i meditsiny
Germ-free monoflora (contaminated with nonpathogenic spore-bearing bacillus) and common albino rats (OFA) were infected with V. cholera El Tor, of Ogava and Inaba serological types (6 milliard microbial cells per 1.5 ml of physiological solution per rat). Appr...
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Modeling Microcirculatory Disorders Using An Ultraviolet Laser
Biulleten' eksperimental'no? biologii i meditsiny
Reactions of microvessels and mast cells to laser irradiation were studied in rat mesentery by applying the method of intravital microscopy. An ultra-violet laser (gamma=337 nm) was used. The diameter of the laser beam was changed from 2 to 100 mum. Different ...
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Experimental Trigeminal Neuralgia (With Reference To The Concept Of The Generator Mechanism Of The Pain Syndrome)
Biulleten' eksperimental'no? biologii i meditsiny
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Focal Lesions Of Somatic Musculature Induced By Dimethylparaphenylenediamine
Biulleten' eksperimental'no? biologii i meditsiny
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Modification Of Structural Transitions Of Supramolecular Nucleoprotein Systems Induced By The Protein Component Of Deoxyribonucleoprotein From Malignant Cells
Biulleten' eksperimental'no? biologii i meditsiny
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Induction Of Angiogenic Sarcomas By Mammalian Adenoviruses
Biulleten' eksperimental'no? biologii i meditsiny
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Pigment Tumors In Rats Caused By The Implantation Of Platinum And Cellophane Films Into The Eye Chamber
Biulleten' eksperimental'no? biologii i meditsiny
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Spontaneous Mammary Tumors In Dogs As A Model For Experimental Antineoplastic Therapy
Biulleten' eksperimental'no? biologii i meditsiny
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Factors Promoting The Development Of Experimental Cholera In Puppies
Biulleten' eksperimental'no? biologii i meditsiny