Although the coexistence of thymus disease with candidiasis has been mentioned, the association of generalized cutaneous candidiasis with thymoma has apparently been documented only once before. This report describes such an association in a second patient in whom another thymus-related disease, diffuse myopathy, was also present. Surgical removal of the tumor, a thymoma of the spindle cell variety, did not result in improvement of the myopathy nor of the candidiasis. Cutaneous lesions of candidiasis responded to local anticandida agents, but they relapsed when the therapy was discontinued and showed a tendency to worsen when steroid therapy for the myositis was started. It would appear that thymoma should be added to the list of abnormal general states that may predispose to candidiasis.

Although recent studies have hinted at associations between allergic contact dermatitis (ACD) and infectious diseases, extensive cohort analyses on the direct correlations between ACD and increased susceptibility to these infections remain limited. After analysing the ‘All of Us’ database, which includes a diverse cohort of 287 011 participants, the study identified 4854 patients with ACD. Comparisons with matched controls revealed a significant association between ACD and various infectious cutaneous comorbidities. Specifically, individuals with ACD showed a heightened risk of conditions like impetigo, scabies, cutaneous herpes simplex virus, cutaneous candidiasis, cutaneous abscess and verruca vulgaris.

The cutaneous manifestations of 18 infants treated for systemic candidiasis during a 3 3/4-year period were examined. Eight infants, with a mean birth weight of 712 +/- 161 g, had a diffuse burn-like dermatitis, usually within the first three days of life. Candida pseudohyphae were identifiable on skin scrapings. A history of a maternal cerclage or intrauterine device complicated by chorioamnionitis was common. A delay in diagnosis or therapy resulted in mortality, whereas promptly treated infants survived. Nine additional infants had monilial diaper rashes, which spread to the trunk and extremities in four infants. These infants were older at the onset of the dermatitis, and all survived the systemic infection. Systemic candidiasis without any cutaneous involvement developed in only one infant. Candidiasis should be more frequently considered, and prompt systemic therapy should be instituted when cutaneous candidiasis occurs within the first few days of life in infants who weigh less than 1,500 g.

<jats:p>The cutaneous manifestations of 18 infants treated for systemic candidiasis during a 3¾-year period were examined. Eight infants, with a mean birth weight of 712 ± 161 g, had a diffuse burn-like dermatitis, usually within the first three days of life. Candida pseudohyphae were identifiable on skin scrapings. A history of a maternal cerclage or intrauterine device complicated by chorioamnionitis was common. A delay in diagnosis or therapy resulted in mortality, whereas promptly treated infants survived. Nine additional infants had monilial diaper rashes, which spread to the trunk and extremities in four infants. These infants were older at the onset of the dermatitis, and all survived the systemic infection. Systemic candidiasis without any cutaneous involvement developed in only one infant. Candidiasis should be more frequently considered, and prompt systemic therapy should be instituted when cutaneous candidiasis occurs within the first few days of life in infants who weigh less than 1,500 g.</jats:p>

A case of an 8 year old girl with granulomatous candidiasis and impaired cell mediated immunity, is presented. The pathogenesis, associated diseases and the treatment of chronic mucocutaneous candidiasis are discussed.

Abstract Amphotericin B, in cream and lotion formulations, has been compared with certain other medications in the topical treatment of intertriginous candidiasis, cutaneous candidiasis, and paronychial candidiasis. References 1. Sulzberger, M.B., et al: Diagnosis and Treatment in Dermatology (ed 2), Chicago: Year Book Publishing Co., 1961, pp 75, 77, 103, 106. 2. Sulzberger, M.B., and Witten, V.H.: " Dermatologic Drugs " in W. Modell (ed) Drugs of Choice 1962-1963 , St. Louis: C. V. Mosby Co., 1962, p 731. 3. Kozinn, P.J., et al: " Treatment of Cutaneous Candidiasis in Infancy and Childhood With Nystatin and Amphotericin B ," Antibiotics Annual 1956-1957 , H. Welch and F. Marti-Ibanez, (eds) New York: Medical Encyclopedia, 1957, p 128. 4. Rosenthal, A.L.: Effect of Amphotericin B. Lotion in Cutaneous Moniliasis , Arch Derm 87:270, 1963.Crossref 5. Orentreich, N.: Amphotericin B, a New Topical Agent for Cutaneous Candidiasis , Curr Ther Res 4:182, 1962. 6. Robinson, M.M.: A Therapeutic Comparison of Amphotericin B and Nystatin in Cutaneous Candidiasis , Milit Med 127:345, 1962. 7. Kligman, A.M.: The Biology of Experimental Cutaneous Moniliasis (Candida albicans) , Arch Derm 85:233, 1962.Crossref

Abstract • Disseminated candidiasis usually occurs in profoundly immunocompromised hosts. We describe a case of disseminated macronodular cutaneous candidiasis in a man with no known risk for immunosuppression other than alcoholic liver disease and a second case of multiple macronodular cutaneous abscesses in an alcoholic man who had no evidence of systemic dissemination. One patient had testicular candidiasis, a previously unreported site of infection in disseminated candidiasis. Tests showed neutrophil and lymphocyte function to be normal; however, a marked defect in serum opsonization was demonstrated in one patient. It is postulated that chronic alcoholism with alcoholic liver disease resulted in impaired serum opsonization, which, in turn, predisposed these patients to candidal infection. (Arch Intern Med 1986;146:385-386) References 1. Bodey GP, Luna M: Skin lesions associated with disseminated candidiasis. JAMA 1974;229:1466-1468.Crossref 2. Arena FP, Perlin M, Brahman H, et al: Fever, rash, and myalgias of disseminated candidiasis during antifungal therapy. Arch Intern Med 1981;141:1233.Crossref 3. Runyon BA, Morrissey RL, Hoefs JC, et al: Opsonic activity of human ascitic fluid: A potentially important protective mechanism against spontaneous bacterial peritonitis. Hepatology 1985;5:634-637.Crossref 4. Wilson JW: Cutaneous (chancriform) syndrome in deep mycoses. Arch Dermatol 1963;87:81-85.Crossref 5. Rose HD, Varkey B: Deep mycotic infection in the hospitalized adult: A study of 123 patients. Medicine 1975;54:499-507.Crossref 6. Rimola A, Soto R, Bory F, et al: Reticuloendothelial system phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis. Hepatology 1984;4:53-58.Crossref 7. Larcher VF, Wyke RJ, Mowat AP, et al: Bacterial and fungal infection in children with fulminant hepatic failure: Possible role of opsonization and complement deficiency. Gut 1982;23:1037-1043.Crossref 8. Wright CD, Bowie JU, Gray GR, et al: Candidacidal activity of myeloperoxidase: Mechanisms of inhibitory influence of soluble cell wall mannan. Infect Immun 1983;42:76-80. 9. Nelson RD, Herron MJ, McCormack RT, et al: Two mechanisms of inhibition of human lymphocyte proliferation by soluble yeast mannan polysaccharide. Infect Immun 1984;43:1041-1046. 10. Seay TE, Inman FP: Amphotericin B modifications of peripheral blood lymphocyte and tonsil lymphocyte responses to concanavalin A. Int J Immunopharmacol 1982;4:549-556.Crossref 11. Staples PJ, Boujak J, Douglas RG Jr, et al: Disseminated candidiasis in a previously healthy girl: Implication of a leukocyte candidacidal defect. Clin Immunol Immunopathol 1977;7:157-167.Crossref