11 castrate female rats were treated with intrauterine injections of a solution of estrone in corn oil; 11 additional castrate female rats were administered with the same solution by daily subcutaneous injections. Vaginal smears in both groups showed continuous estrus, distended uteri and squamous metaplasia of the uterine epithelium, with downgrowth into the stroma. Similar quantities of estrone administered to 12 normal male rats produced marked atrophy of the penis, testes, seminal vesicles, and prostate, but no metaplasia was observed, even when estrone was injected directly into the seminal vesicles. Administration of 1:2:5:6-dibenzanthracene in oil, gas-house tar, or pregnandiol in female rats did not cause metaplasia of the uterine epithelium, although the first 2 preparatoin are known to be carcinogenic.
Metaplasia of uterine epithelium produced in rats by prolonged administration of oestrin.
Abstract
11 castrate female rats were treated with intrauterine injections of a solution of estrone in corn oil; 11 additional castrate female rats were administered with the same solution by daily subcutaneous injections. Vaginal smears in both groups showed continuous estrus, distended uteri and squamous metaplasia of the uterine epithelium, with downgrowth into the stroma. Similar quantities of estrone administered to 12 normal male rats produced marked atrophy of the penis, testes, seminal vesicles, and prostate, but no metaplasia was observed, even when estrone was injected directly into the seminal vesicles. Administration of 1:2:5:6-dibenzanthracene in oil, gas-house tar, or pregnandiol in female rats did not cause metaplasia of the uterine epithelium, although the first 2 preparatoin are known to be carcinogenic.
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Metaplasia of uterine epithelium produced in rats by prolonged administration of oestrin.
Mceuen, C. S.
The American journal of cancer
MEDLINE Abstracts – May 1, 1936
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