The growth processes induced by estrogenic hormones which take place in the uterus of the mouse are investigated. The uterus and other sex organs were studied in 501 mice including 177 control mice which were not subjected to sex hormones. 3 different strains of mice of ages ranging from 1-20 months were used. Mice were variously injected with 1-100 rat units of estrogen, estrogen and acid extract of cattle anterior pituitary gland, acid extract alone, estrogen and corpus luteum extract (Proluton), and corpus luteum alone. Changes which may take place in the uterus of mice under the influence of estrogen include: 1) the normal one-layered cylindrical epithelium may change into several rows of cylindrical cells or into a partly cylindrical and partly squamous epithelium, or a typical squamous epithelium; 2) gland ducts may become cystically dilated and filled with colloid material; 3) the uterine glands may proliferate and penetrate into and through the muscle tissue; 4) infection may take place; and 5) parts of the pancreas may become adherent to the uterus. In none of the test cases were cancerous changes or even precancerous proliferations found. Reactivity of the uterine epithelial structures to growth stimulation is less than that
Growth processes induced by estrogenic hormones in the uterus of the mouse.
Abstract
The growth processes induced by estrogenic hormones which take place in the uterus of the mouse are investigated. The uterus and other sex organs were studied in 501 mice including 177 control mice which were not subjected to sex hormones. 3 different strains of mice of ages ranging from 1-20 months were used. Mice were variously injected with 1-100 rat units of estrogen, estrogen and acid extract of cattle anterior pituitary gland, acid extract alone, estrogen and corpus luteum extract (Proluton), and corpus luteum alone. Changes which may take place in the uterus of mice under the influence of estrogen include: 1) the normal one-layered cylindrical epithelium may change into several rows of cylindrical cells or into a partly cylindrical and partly squamous epithelium, or a typical squamous epithelium; 2) gland ducts may become cystically dilated and filled with colloid material; 3) the uterine glands may proliferate and penetrate into and through the muscle tissue; 4) infection may take place; and 5) parts of the pancreas may become adherent to the uterus. In none of the test cases were cancerous changes or even precancerous proliferations found. Reactivity of the uterine epithelial structures to growth stimulation is less than that
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Growth processes induced by estrogenic hormones in the uterus of the mouse.
Loeb, L.; Suntzeff, V.; Burns, E. L.
The American journal of cancer
MEDLINE Abstracts – Nov 1, 1938
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