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The spermatogenic rebound effect was studied in 5 oligospermic males after testosterone-induced azoospermia. The subjects received 3 weekly doses (50 mcg) of testosterone propionate for 2 1/2 - 4 1/2 months. Seminal fluid analysis was conducted every 6-8 weeks after treatment was terminated. In each case, spermatogenic activity gradually increased after the last treatment until the production of mature spermatozoa exceeded pretreatment levels. A marked improvement was also seen in the posttreatment histologic picture when compared with pretreatment specimens. It is not known whether the rebound response is peculiar to androgenic substances.

Spermatogenic rebound phenomenon after administration of testosterone propionate.

Abstract

The spermatogenic rebound effect was studied in 5 oligospermic males after testosterone-induced azoospermia. The subjects received 3 weekly doses (50 mcg) of testosterone propionate for 2 1/2 - 4 1/2 months. Seminal fluid analysis was conducted every 6-8 weeks after treatment was terminated. In each case, spermatogenic activity gradually increased after the last treatment until the production of mature spermatozoa exceeded pretreatment levels. A marked improvement was also seen in the posttreatment histologic picture when compared with pretreatment specimens. It is not known whether the rebound response is peculiar to androgenic substances.

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Spermatogenic rebound phenomenon after administration of testosterone propionate.

Heckel, N. J.; Rosso, W. A.; Kestel, L.
The Journal of clinical endocrinology
MEDLINE Abstracts – Mar 1, 1951

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