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A case study of testosterone-induced spermatogenesis in a "pan-hypop ituitary" eunochoid is presented. The patient, age 24, exhibited relative dwarfism and complete sexual infanitilism. The patient was treated with testosterone pellets for a period of 5 months. The treatment resulted in significant spermatogenesis and sexual development. Since urinary gonadotropin excretion prior to and during therapy was consistently negative for 4 or less mouse units per 24 hours, it is assumed that testosterone directly affects the seminiferous tubules without mediation by gonadotropins.

Spermatogenesis in a "pan-hypopituitary" eunuchoid, as the result of testosterone therapy.

Abstract

A case study of testosterone-induced spermatogenesis in a "pan-hypop ituitary" eunochoid is presented. The patient, age 24, exhibited relative dwarfism and complete sexual infanitilism. The patient was treated with testosterone pellets for a period of 5 months. The treatment resulted in significant spermatogenesis and sexual development. Since urinary gonadotropin excretion prior to and during therapy was consistently negative for 4 or less mouse units per 24 hours, it is assumed that testosterone directly affects the seminiferous tubules without mediation by gonadotropins.
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Spermatogenesis in a "pan-hypopituitary" eunuchoid, as the result of testosterone therapy.

Kinsell, L. W.
The Journal of clinical endocrinology
MEDLINE Abstracts – Dec 1, 1947

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